{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:55:09Z","timestamp":1790247309920,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>COVID\u201019 during pregnancy is linked to increased maternal morbidity and a higher incidence of preterm births (PTBs), yet the underlying mechanisms remain unclear. Cellular senescence, characterized by the irreversible cessation of cell division, is a critical process in placental function, and its dysregulation has been implicated in pregnancy complications like PTB. Senescence can be induced by various stressors, including oxidative stress, DNA damage, and viral infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>\n                      In this study, we determined whether COVID\u201019 had an impact on placental senescence. We examined placentas from women infected with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) (\n                      <jats:italic>n<\/jats:italic>\n                      = 10 term, 4 preterm) compared to uninfected controls (\n                      <jats:italic>n<\/jats:italic>\n                      = 10 term, 3 preterm). The placentas were analyzed for SARS\u2010CoV\u20102 infection (spike and nucleocapsid viral proteins), markers of DNA damage (\u03b3H2AX) and oxidative stress (ROS), and senescence (telomere length, cell cycle regulators, and senescence\u2010associated secretory phenotype [SASP]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although no overall differences in cellular senescence markers were observed between the COVID\u201019 positive and negative groups, we found increased secreted SASP markers. Confocal microscopy of placentas from COVID\u201019 positive cases revealed localized areas of oxidative stress and DNA damage colocalized with SARS\u2010CoV\u20102 spike protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that SARS\u2010CoV\u20102 infection induces localized focal placental damage, warranting further investigation into its impact on maternal and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70034","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T06:24:21Z","timestamp":1735539861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Placentas From SARS\u2010CoV\u20102 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-4256","authenticated-orcid":false,"given":"Guilherme M.","family":"Nobrega","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"},{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-2788","authenticated-orcid":false,"given":"Eliza R.","family":"McColl","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-4407","authenticated-orcid":false,"given":"Arthur","family":"Antolini\u2010Tavares","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"},{"name":"Department of Pathology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-9269","authenticated-orcid":false,"given":"Renato T.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-8445","authenticated-orcid":false,"given":"Jos\u00e9 Guilherme","family":"Cecatti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-8677","authenticated-orcid":false,"given":"Indira U.","family":"Mysorekar","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases Baylor College of Medicine Houston Texas USA"},{"name":"Department of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas USA"},{"name":"Huffington Center on Aging Baylor College of Medicine Houston Texas 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