{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:32:07Z","timestamp":1774474327331,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Given the ongoing challenges regarding the specific roles of viral infections in cancer etiology, or as cancer co\u2010morbidities, this study assessed potential associations between anti\u2010viral, T\u2010cell receptor (TCR) complementarity domain region\u20103 (CDR3s), and clinical outcomes for ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TCR CDR3s were isolated from ovarian cancer specimens for a determination of which patients had anti\u2010viral CDR3s and whether those patients had better or worse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses revealed that patients with exact matches of anti\u2010Epstein\u2013Barr virus (EBV) CDR3 amino acid sequences exhibited better outcomes for both overall and disease\u2010specific survival. However, better outcomes were not observed when assessing anti\u2010viral CDR3s representing cytomegalovirus, influenza A, or Sars\u2010CoV\u20102. Due to previous occurrences of the occasional misdiagnoses of lymphoma as ovarian cancer, the frequency of anti\u2010EBV CDR3s in lymphoma patients was determined. These frequencies were relatively high, particularly for diffuse large B\u2010cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings (i) underscore the potential value of anti\u2010EBV immune responses in terms of patient outcomes; (ii) raise questions about the potential value of anti\u2010EBV immunotherapies; and (iii) support further inquiry into the relationship between EBV infection and previously reported cases of ovary\u2010resident lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70046","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T14:53:20Z","timestamp":1737125600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Better Outcomes for Ovarian Cancer Associated With the Detection of Anti\u2010EBV TCR CDR3s: Potential Relevance to Diffuse Large B\u2010Cell Lymphoma"],"prefix":"10.1111","volume":"93","author":[{"given":"Nandini","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline C.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Aboujaoude","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine University of South Florida Tampa Florida 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