{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:59:28Z","timestamp":1777557568554,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our previous study has identified an association of a single nucleotide polymorphism (SNP) in the <jats:italic>miR\u2010423<\/jats:italic> gene with recurrent spontaneous abortion (RSA). The presence of additional RSA\u2010linked SNPs in the <jats:italic>miR\u2010423<\/jats:italic> gene remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated polymorphisms in the coding region of <jats:italic>miR\u2010423<\/jats:italic> in Han Chinese women with unexplained RSA (URSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were observed in the genotype and allele distribution of <jats:italic>miR\u2010423<\/jats:italic> rs8067576 between patients with RSA and control subjects. A robust association was found between an elevated RSA incidence and the presence of A\/T heterozygosity in <jats:italic>miR\u2010423<\/jats:italic> rs8067576, with an odds ratio (OR) of 1.76 (95% confidence interval [CI]: 1.26 to 2.47, <jats:italic>p<\/jats:italic> = 0.000292). The rare allele <jats:italic>T<\/jats:italic> in the pre\u2010<jats:italic>miR\u2010423<\/jats:italic> sequence was shown to cause a discernible structural change and a reduced \u0394G value. Compared with the <jats:italic>A<\/jats:italic> allele, the rare <jats:italic>T<\/jats:italic> allele promoted cell proliferation. Furthermore, compared with the <jats:italic>T<\/jats:italic> allele, the <jats:italic>A<\/jats:italic> allele in the rs8067576 polymorphism exhibited a greater ability to inhibit the translation of proliferation\u2010associated 2 group 4 (Pa2g4), which is the functional target of <jats:italic>miR\u2010423<\/jats:italic>. The <jats:italic>T<\/jats:italic> allele in the rs8067576 polymorphism was also found to be more susceptible to the inhibition of cell proliferation induced by mifepristone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rs8067576 <jats:italic>A<\/jats:italic> &gt; <jats:italic>T<\/jats:italic> polymorphism in the <jats:italic>miR\u2010423<\/jats:italic> gene may serve as a genetic susceptibility locus for RSA. This polymorphism appears to contribute to an increased risk of acquiring URSA in humans by destroying mature <jats:italic>miR\u2010423<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70050","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T17:13:49Z","timestamp":1737998029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>MiR\u2010423<\/i> Coding Region Genetic Polymorphism rs8067576 May Associate With the Risk of Developing Recurrent Spontaneous Abortion: A Case\u2010Control Study in a Chinese Han Population"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-9604","authenticated-orcid":false,"given":"Xing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Reproductive Genetics Tangshan Maternal and Child Health Hospital  Tangshan Hebei China"},{"name":"Reproductive and Genetic Center &amp; NHC Key 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 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center &amp; NHC Key Laboratory of Reproductive Health Engineering Technology Research, National Research Institute for Family Planning (NRIFP)  Beijing China"},{"name":"Graduate Schools, Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center &amp; NHC Key Laboratory of Reproductive Health Engineering Technology Research, National Research Institute for Family Planning (NRIFP)  Beijing China"},{"name":"Graduate Schools, Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center &amp; NHC Key Laboratory of 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