{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:46:57Z","timestamp":1782773217894,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the first\u2010trimester combined inflammatory markers between pregnant women diagnosed with ulcerative colitis (UC) and healthy pregnant women. Furthermore, to investigate the predictive value of these markers for adverse obstetric outcomes in pregnant women affected by UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, data were collected from pregnant women with UC who gave birth at our hospital between January 2021 and May 2024 and from a control group of healthy pregnant women. A comparison was made between the two groups in terms of their demographic characteristics, neonatal outcomes, and the values of the first\u2010trimester neutrophil\u2010to\u2010lymphocyte ratio (NLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), and aggregated index of systemic inflammation (AISI). Furthermore, the relationship between these combined inflammatory markers and adverse obstetric outcomes in pregnant women with UC was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No notable discrepancy was observed between the UC group and the control group with respect to SIRI and AISI. The first\u2010trimester NLR and SII values were observed to be higher in the UC group in comparison to the control group. The data indicated that pregnant women with UC who experienced poor obstetric outcomes exhibited elevated levels of NLR, SII, SIRI, and AISI during the first trimester. In the ROC analysis, the predictive capacity of all four parameters for poor obstetric outcomes in UC patients was statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is an association between elevated combined inflammatory markers in the first trimester and poor obstetric outcomes in pregnant women with UC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70055","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:48:37Z","timestamp":1738849717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of First\u2010Trimester Combined Inflammatory Markers (NLR, SII, SIRI, and AISI) With Poor Obstetric Outcomes in Pregnancies With Ulcerative Colitis"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-7825","authenticated-orcid":false,"given":"Osman Onur","family":"Ozkavak","sequence":"first","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-8248","authenticated-orcid":false,"given":"Atakan","family":"Tanacan","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-8138","authenticated-orcid":false,"given":"Hakki","family":"Serbetci","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-2398","authenticated-orcid":false,"given":"Esra","family":"Karatas","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-3828","authenticated-orcid":false,"given":"Murat","family":"Haksever","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-3316","authenticated-orcid":false,"given":"Ezgi","family":"Basaran","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1110-2220","authenticated-orcid":false,"given":"Melike Busra","family":"Atar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9048","authenticated-orcid":false,"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30333\u20104"},{"key":"e_1_2_9_3_1","first-page":"614","article-title":"Expression of HLA\u2010DR Antigens by Colonic Epithelium in Inflammatory Bowel Disease","volume":"53","author":"Selby W. 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