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These TPD methods, such as autophagosome\u2010tethering compounds (ATTEC), autophagy\u2010targeting chimera (AUTAC), AUTOphagy\u2010TArgeting chimera (AUTOTAC), and chaperone\u2010mediated autophagy (CMA) targeting chimera, exhibit efficacy in degrading misfolded protein aggregates associated with neurodegenerative disorders. Moreover, the excessive accumulation of misfolded proteins or protein complexes in the placenta has been identified as a significant contributor to preeclampsia (PE). Given the lack of effective treatments for PE, the application of autophagy\u2010mediated TPD technology presents a novel therapeutic avenue. This review draws parallels between misfolded protein aggregates in neurodegenerative diseases and placenta\u2010derived PE, integrating a substantial number of full\u2010text studies. By harnessing TPD technologies grounded in the ALP, these autophagic degraders offer a pioneering approach for targeted therapy in PE by dismantling potential targets. Presently, there is limited exploration of ALP technology for identifying target proteins in the placenta. 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