{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:37:08Z","timestamp":1793752628086,"version":"4.6.1"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>To investigate the value of the first\u2010trimester aggregate index of systemic inflammation (AISI) and other combined inflammatory markers in the prediction of gestational diabetes mellitus (GDM) and related obstetric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>The data of pregnant women diagnosed with GDM between September 2021 and November 2024, as well as an equal number of control patients, were retrospectively analyzed. The patients' AISI, neutrophil lymphocyte ratio (NLR), systemic immune\u2010inflammatory index (SII), and systemic inflammatory response index (SIRI) values were calculated from the hemogram parameters of the participants at 11\u201314 weeks of gestation. The clinical characteristics, laboratory results, combined inflammatory indices, obstetric outcomes, the need for neonatal intensive care unit (NICU) admission, and the presence of composite adverse perinatal outcome (CAPO) of the groups were then compared. Receiver operating characteristic (ROC) curve analyses were performed to investigate the value of the indices that reached statistical significance in predicting GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GDM group exhibited significantly higher SII and AISI values, rate of NICU admission, and CAPO compared to the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01, and <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01, respectively). The gestational age at birth was significantly lower in the GDM group compared to the control group, while the neonatal weight was higher (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01, respectively). The ROC curve analyses yielded an area under the curve (AUC) of 0.566 and 0.581 for SII and AISI for GDM prediction, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010trimester AISI and SII may be useful markers for identifying pregnancies at high risk for developing GDM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70069","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T16:06:11Z","timestamp":1743869171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictive Value of First\u2010Trimester Aggregate Index of Systemic Inflammation (AISI) and Other Inflammatory Indices for Gestational Diabetes Mellitus and Associated Obstetric Outcomes"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-2398","authenticated-orcid":false,"given":"Esra","family":"Karatas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-8248","authenticated-orcid":false,"given":"Atakan","family":"Tanacan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-7825","authenticated-orcid":false,"given":"Osman Onur","family":"Ozkavak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6644-3890","authenticated-orcid":false,"given":"Burcu Bozkurt","family":"Ozdal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Betul","family":"Ucar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4204-0014","authenticated-orcid":false,"given":"Ozgur","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"},{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9048","authenticated-orcid":false,"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Ankara Bilkent City Hospital  Ankara Turkey"},{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"1","article-title":"Trends and Characteristics in Gestational Diabetes: United States, 2016\u20132020","volume":"71","author":"Gregory E. C.","year":"2022","journal-title":"National Vital Statistics Reports"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20102941"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6743a2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102021\u2010067946"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0335"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010021909\u2010135846"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S378309"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.925690"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010023\u201003661\u20106"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2024.111575"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.10.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20100442"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30057"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14557"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100785"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010018\u20102131\u20104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.285"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010020\u20102759\u20108"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.3189"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195736"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101812"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010129"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084261"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1115619"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010022\u201005245\u2010y"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.21613\/GORM.2023.1469"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010328406"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201712_14016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.21613\/GORM.2023.1471"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041\u2010008x(67)90056\u20107"},{"issue":"1","key":"e_1_2_9_35_1","first-page":"5","article-title":"Ratio of Neutrophil to Lymphocyte Counts\u2014Rapid and Simple Parameter of Systemic Inflammation and Stress in Critically Ill","volume":"102","author":"Zahorec R.","year":"2001","journal-title":"Bratislavske Lekarske Listy"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead261"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2021.1986476"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.03.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010022\u201005335\u20101"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.07.005"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6668381"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S414305"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.11.003"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1780579"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2024.2371979"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2021.1926542"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab051"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19\u20100976"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2023.441"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030511"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806\u20109282.20240532"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18856"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010020\u201001974\u2010w"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25691"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.537140"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.933913"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1090305"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15533"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28181"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44063"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S474154"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15442"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003236"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211064744"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010023\u201001446\u20103"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1212998"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010024\u201001506\u2010x"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11236982"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144584"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184134"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64007"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202309_33807"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201068956\u2010w"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15868"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010024\u201006821\u20104"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T09:12:51Z","timestamp":1745399571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/aji.70069"],"URL":"https:\/\/doi.org\/10.1111\/aji.70069","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70069"}}