{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:28:17Z","timestamp":1775478497593,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively evaluate whether endometrial fluid detected at transvaginal ultrasonography on the third day of the menstrual cycle in infertile patients undergoing in vitro fertilization\/intracytoplasmic sperm injection\u2013embryo transfer (IVF\u2010ICSI\/ET) affects pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 148 patients who had undergone IVF\u2010ICSI between 2010 and 2017 were included in this study. The participants were stratified according to the presence of endometrial fluid: Group 1 (control; <jats:italic>n<\/jats:italic> = 74) consisted of women without endometrial fluid and Group 2 (study; <jats:italic>n<\/jats:italic> = 74) of those with endometrial fluid. Baseline sociodemographic characteristics and reproductive outcomes were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference was found between the groups in terms of age, body mass index, smoking rates, duration of infertility, etiology of infertility, baseline follicle\u2010stimulating hormone, luteinizing hormone, estradiol, thyroid\u2010stimulating hormone, and prolactin levels, duration of stimulation, stimulation protocol, antral follicle counts, total gonadotropin doses, peak E<jats:sub>2<\/jats:sub> and progesterone levels on the day of human chorionic gonadotropin (hCG) administration, or endometrial thickness at hCG administration and the day of transfer (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The number of oocytes retrieved, metaphase II oocytes, two pronuclei, fertilization rates, and the rates of Grade I embryos per woman, as well as pronucleus counts, were comparable between the groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). However, the clinical pregnancy rate (CPR) (47.3% vs. 31.1%) and live birth rate (LBR) (41.9% vs. 24.3%) were both significantly lower in women with endometrial fluid compared to the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective cohort study shows that the women with endometrial fluid in their IVF\u2010ICSI\/ET cycles exhibited lower CPR and LBR. Further prospective studies are needed to confirm the validity of our results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70072","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T16:52:53Z","timestamp":1743871973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproductive Outcomes of Women With Endometrial Fluid During IVF\u2010ICSI Treatment: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6312-7520","authenticated-orcid":false,"given":"Burcu Tas","family":"Uzun","sequence":"first","affiliation":[{"name":"Akdeniz University Medical Faculty, IVF Unit  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-5470","authenticated-orcid":false,"given":"Emine Sen","family":"Bicak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Akdeniz University Medical Faculty  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-0359","authenticated-orcid":false,"given":"Erinc","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-7908","authenticated-orcid":false,"given":"Hasan Ali","family":"Inal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-4054","authenticated-orcid":false,"given":"Mete","family":"Caglar","sequence":"additional","affiliation":[{"name":"Akdeniz University Medical Faculty, IVF Unit  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-024-01314-7"},{"key":"e_1_2_9_5_1","article-title":"Study of Sonographic Indicators of Ovarian Reserves in Women With WHO\u2010Defined Anovulatory Disorders","volume":"16","author":"Hans P.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676109"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0340-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00973-8"},{"key":"e_1_2_9_9_1","article-title":"Generation of Epithelial\u2010Stromal Assembloids as an Advanced in Vitro Model of Impaired Adenomyosis\u2010Related Endometrial Receptivity","author":"Stratopoulou C. 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