{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:39:32Z","timestamp":1787647172366,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["Program\u00a0No.\u00a02022YFC2704400"],"award-info":[{"award-number":["Program\u00a0No.\u00a02022YFC2704400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Chronic endometritis has been shown to cause infertility, and chronic inflammation has been confirmed to be associated with the development of cancer. However, the effect of chronic endometritis on endometrial hyperplasia (EH) among infertile women has not been studied. So, we aim to investigate whether chronic endometritis affects the prognosis and reproductive outcome in infertile women with EH who had preserved fertility therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study employed a retrospective design. Infertile women who underwent hysteroscopic biopsy and were diagnosed as EH were enrolled. We used CD138 immunohistochemical staining in endometrium paraffin sections of EH patients. The patients were divided into two groups according to whether they were diagnosed as chronic endometritis or not, and the disease outcome and reproductive outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The results showed that after progesterone therapy, women with a persistent chronic endometritis exhibited a lower rate of complete response (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.002) of EH, along with an increased incidence of miscarriage after embryo transfer (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates a high prevalence rate of chronic endometritis in infertile women with EH, with potential implications for prognosis and subsequent reproductive outcomes, whether antibiotics should be added to the treatment of patients with EH combined with chronic endometritis deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70075","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T17:15:44Z","timestamp":1746983744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Chronic Endometritis on Prognosis and Reproductive Outcomes in Infertile Women With Endometrial Hyperplasia"],"prefix":"10.1111","volume":"93","author":[{"given":"Xiaotong","family":"Dong","sequence":"first","affiliation":[{"name":"Medical Integration and Practice Center Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Center for Reproductive Medicine Institute of Women Children and Reproductive Health Shandong University  Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University  Jinan Shandong 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