{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:47:16Z","timestamp":1769942836764,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42175181"],"award-info":[{"award-number":["42175181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42375180"],"award-info":[{"award-number":["42375180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Preeclampsia (PE) and bronchopulmonary dysplasia (BPD) are severe disorders that significantly affect maternal and neonatal health worldwide. This study evaluated the predictive value of maternal hematologic indicators in PE patients for the risk of offspring BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A retrospective cohort study was conducted enrolling infants born before 34 weeks\u2019 gestation between September 2017 and December 2019 at the Third Affiliated Hospital of Guangzhou Medical University. Logistic regression analysis was used to evaluate the association between maternal hematologic indicators and offspring BPD. Subgroup analysis was performed to explore the interaction effects between maternal hematologic indicators and PE on neonatal BPD risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 510 preterm infants and their mothers were analyzed. After adjusting for potential confounders, interaction effects between maternal white blood cell count (WBC), absolute neutrophil count (ANC), and PE on offspring BPD were observed (<jats:italic>p<\/jats:italic> for interaction &lt;0.05). Among normotensive mothers, elevated WBC or ANC did not significantly increase the risk of offspring BPD (OR [95% CI]: 1.02 [0.93\u20131.12] for both). In contrast, in PE patients, higher levels of WBC and ANC were independently associated with offspring BPD risk (OR [95% CI]: 1.24 [1.06\u20131.47] and 1.22 [1.05\u20131.44], respectively). Moreover, WBC &gt; 11.90 and NLR &gt; 7.65 in PE patients were identified as independent predictors of neonatal BPD (OR [95% CI]: 4.88 [1.27\u201321.04] and 4.67 [1.41\u201317.27], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neutrophil\u2010related hematologic indicators, including WBC, ANC, and NLR in PE patients, are significantly and independently associated with the development of BPD. These findings highlight the potential of neutrophils as a promising focus for investigating the relationship between these maternal and neonatal disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70078","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:17:41Z","timestamp":1745925461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal Neutrophil Inflammation Markers Predict Bronchopulmonary Dysplasia in Preeclamptic Pregnancies"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1917-4023","authenticated-orcid":false,"given":"Tifeng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Neonatology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"},{"name":"Clinical Medical College, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Neonatology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"},{"name":"Clinical Medical College, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiting","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Neonatology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"},{"name":"Clinical Medical College, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Guangzhou Medical University  Guangzhou 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Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine School of Medicine, Jinan University  Guangzhou China"},{"name":"China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Center for Disease Control and Prevention  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neonatology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University  Guangzhou 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