{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:46:04Z","timestamp":1789159564867,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["121S341"],"award-info":[{"award-number":["121S341"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>In order to gain a deeper understanding of the mechanisms underlying LPS\u2010mediated preterm birth, it is crucial to investigate the relationship between preterm birth and mast cells (MCs). Moreover, the role of antihistamines in inflammatory processes during pregnancy remains incompletely understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>CD\u20101 female mice were administered intrauterine lipopolysaccharide (LPS) via midline laparotomy to establish an inflammation\u2010induced preterm birth model. The experimental groups (<jats:italic>n<\/jats:italic> = 6 per group) were formed as Nonpregnant and pregnant control, Sham, PBS, LPS, Cetirizine (CET) control, and two CET treatment groups (CET 10\u00a0mg\/kg\u2010low dose, and CET 20\u00a0mg\/kg\u2010high dose with LPS administration). Tissue samples were analyzed using immunohistochemistry and Western blot techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings suggest that MCs play a significant role in preterm birth, with LPS administration inducing MC dysfunction in the reproductive tract during pregnancy. Additionally, high doses of CET may support inflammatory responses. A particularly notable result was the reduction in interleukin\u201033 (IL\u201033) expression in the cervix during LPS\u2010induced preterm birth. This suggests that IL\u201033 may serve as a potential biomarker for preterm birth in the cervix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effects of CET during LPS\u2010mediated preterm birth appear to be dose\u2010dependent, warranting further exploration of their role in this context.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70085","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T08:22:32Z","timestamp":1748074952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decreased IL\u201033 Expression in the Cervix in LPS\u2010Induced Preterm Birth and the Potential Role of Mast Cells: A Murine Model"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-5592","authenticated-orcid":false,"given":"Sema","family":"Avci","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Alanya Alaaddin Keykubat University, School of Medicine  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-8680","authenticated-orcid":false,"given":"Ciler","family":"Celik\u2010Ozenci","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Koc University, School of Medicine  Istanbul Turkey"},{"name":"Koc University Research Center for Translational Medicine (KUTTAM)  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-1142","authenticated-orcid":false,"given":"Nilay","family":"Kuscu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Akdeniz University, School of Medicine  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-2950","authenticated-orcid":false,"given":"Nayce Ilayda","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Akdeniz University, School of Medicine  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006\u20100860"},{"key":"e_1_2_10_3_1","unstructured":"WHO.Born Too Soon: The Global Action Report on Preterm Birth.2023."},{"issue":"2","key":"e_1_2_10_4_1","first-page":"100","article-title":"Premature Delivery and the Millennium Development Goal","volume":"5","author":"Nour N. 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