{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:40:23Z","timestamp":1789130423687,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013015","name":"Cedars-Sinai Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008337","name":"Norman Cousins Center for Psychoneuroimmunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Despite adverse maternal and child consequences, postpartum depression 1.6\u20133 years post\u2010delivery remains poorly understood, particularly anhedonia (lack of interest or pleasure), which can harm maternal\u2013child relationships. Understanding the biological pathways underlying maternal depression and identifying biomarkers that contribute to its diverse symptoms is essential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>This study investigated relations between hs\u2010CRP levels and symptoms of depression in mothers 1.6\u20133 years post\u2010delivery (<jats:italic>N<\/jats:italic>\u00a0=\u00a049), and examined associations between specific symptoms of depression and hs\u2010CRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinically elevated symptoms of depression were present in 14.2%. Symptoms of depression were not significantly associated with maternal characteristics but were associated with having a Neonatal Intensive Care Unit (NICU) admission, maternal age, and a recent history of mental illness. Greater depression and anhedonia symptoms were associated with greater levels of hs\u2010CRP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.308, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.314, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). Adjusting for maternal age, BMI, months postpartum, and pregnancy status, elevated depression (not anhedonia) remained associated with higher levels of hs\u2010CRP (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.342, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with clinically elevated symptoms of depression had significantly higher levels of hs\u2010CRP, suggesting that it may be an important inflammatory biomarker for symptoms of depression 1\u20133 years post\u2010delivery and helps identify those in need of follow up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70095","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T08:22:32Z","timestamp":1748074952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anhedonia Symptoms and High Sensitivity C\u2010Reactive Protein (hs\u2010CRP) Several Years Postpartum"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-3554","authenticated-orcid":false,"given":"Jennifer M.","family":"Nicoloro\u2010SantaBarbara","sequence":"first","affiliation":[{"name":"Department of Psychiatry Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, and Medicine Cousins Center for Psychoneuroimmunology, UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margo","family":"Minissian","sequence":"additional","affiliation":[{"name":"Geri &amp; Richard Brawerman Nursing Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-5155","authenticated-orcid":false,"given":"C. Noel Bairey","family":"Merz","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center, Cedars\u2010Sinai Smidt Heart Institute  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eynav E.","family":"Accortt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Cedars\u2010Sinai Medical Center  Los Angeles California 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