{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:12:50Z","timestamp":1773097970359,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Endometritis is an inflammatory disorder often associated with microbial imbalance. Common treatments, such as antibiotics, may lead to drug resistance and do not ensure long\u2010term microbial stability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>This mini review examines vaginal microbiota transplantation (VMT) as a novel approach to the management of endometritis. VMT involves the transfer of healthy microbiota from a donor to restore microbial balance in the recipient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VMT helps maintain vaginal acidity and inhibit pathogenic bacteria by restoring the dominant Lactobacillus spp. One of its key mechanisms is inhibiting the NF\u2010\u03baB signaling pathway, which leads to a decrease in inflammatory cytokines such as IL\u20106, IL\u20101\u03b2, and TNF\u2010\u03b1. This reduces tissue inflammation and improves healing. VMT is also more biocompatible than antibiotics and can be more effective in combination with other treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VMT is a promising noninvasive approach to the treatment of endometritis, with safety and microbial benefits. However, further studies and standardization of methods are needed to confirm its clinical utility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70104","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:30:18Z","timestamp":1749738618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Potential of Vaginal Microbiota Transplantation (VMT) in Endometritis Management"],"prefix":"10.1111","volume":"93","author":[{"given":"Masoud","family":"Lahouty","sequence":"first","affiliation":[{"name":"Pediatric Health Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Abdi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences Faculty of Medicine Tabriz University of Medical Sciences  Tabriz 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