{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:53Z","timestamp":1753878413823,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Fetal growth restriction (FGR) is a significant pregnancy complication associated with impaired placental angiogenesis and endothelial dysfunction, leading to adverse perinatal outcomes. Caveolin\u20101, a structural protein involved in vascular signaling, plays a critical role in regulating angiogenic factors such as VEGF, b\u2010FGF, and eNOS. This study aimed to evaluate the diagnostic potential of serum caveolin\u20101 levels in FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>This prospective case\u2013control study included 37 pregnant women diagnosed with FGR and 33 healthy controls matched for gestational age. Maternal serum caveolin\u20101 levels were measured using ELISA, and their association with clinical parameters, Doppler indices, and neonatal outcomes was analyzed. ROC analysis was performed to assess the diagnostic accuracy of caveolin\u20101 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal serum caveolin\u20101 levels were significantly reduced in the FGR group compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011). Lower caveolin\u20101 levels in FGR were associated with higher Doppler indices (S\/D, PI, RI) and adverse neonatal outcomes, including lower birth weights and Apgar scores. The ROC analysis demonstrated an AuROC of 0.677 with a cutoff value of &lt;222.37\u00a0pg\/mL achieving a sensitivity of 60.6% and a specificity of 59.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced serum caveolin\u20101 levels may be associated with impaired placental angiogenesis and adverse perinatal outcomes in FGR; however, further studies are needed to establish a definitive link. Caveolin\u20101 shows potential as a non\u2010invasive biomarker for early detection and management of FGR. Further research is warranted to validate these findings and explore therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70111","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:14:02Z","timestamp":1749737642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Diagnostic Potential of Caveolin\u20101 in Fetal Growth Restriction: A Prospective Case\u2013Control Study"],"prefix":"10.1111","volume":"93","author":[{"given":"Ruken","family":"Dayanan","sequence":"first","affiliation":[{"name":"Department of Perinatology Ankara Etlik City Hospital  Ankara Turkey"},{"name":"Department of Obstetrics and Gynecology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemal Re\u015fat","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003070"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2018.09.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1500539"},{"key":"e_1_2_10_7_1","first-page":"257","volume-title":"Current Topics in Membranes","author":"Oliveira S. 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