{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:24:14Z","timestamp":1779251054700,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligoovulation or anovulation, and the morphology of polycystic ovaries. Polygonatum odoratum (Mill.) Druce (POD), a key component of the traditional Chinese herb Polygonatum odoratum, has uncertain effects on improving ovarian function and inflammation in patients with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>Network pharmacological analysis was conducted to explore the processes and signaling pathways of POD in the treatment of PCOS. Letrozole via gavage induced the PCOS model rats. Ovarian morphology and the ovarian body index were assessed, and the numbers of corpora lutea and cystic follicles were quantified after hematoxylin\u2012eosin staining. Testosterone and fasting blood glucose levels were measured, and glucose tolerance was evaluated. Additionally, IL\u20101\u03b2 and TNF\u2010\u03b1levels in the ovaries were detected using immunohistochemistry and western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Network pharmacology identified a total of 107 potential targets associated with POD and PCOS, suggested that POD could treat PCOS through mechanisms involving inflammation, the response to LPS, metabolic pathways. Experiments demonstrated that LPS reduced the number of corpora lutea and increased the number of cystic follicles while also impairing glucose regulation in PCOS rats. Moreover, LPS increased the expression levels of IL\u20101\u03b2 and TNF\u2010\u03b1. Treatment with POD mitigated these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that LPS exacerbates ovarian dysfunction and inflammation in PCOS rats, while POD effectively reverses these changes, suggesting a promising avenue for research into the therapeutic potential of traditional Chinese medicine in the treatment of PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70116","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:33:26Z","timestamp":1750750406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polygonatum Odoratum (Mill.) Druce Alleviates Lipopolysaccharide\u2010Induced Inflammation and Improves the Ovarian Function in Polycystic Ovary Syndrome Rats"],"prefix":"10.1111","volume":"94","author":[{"given":"Biao","family":"Zheng","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical University Guilin Guangxi China"},{"name":"Guangxi Province Postgraduate Co\u2010Training Base for Cooperative Innovation in Basic Medicine (Guilin Medical University &amp; Yueyang Maternal and Child Health\u2010Care Hospital) Yueyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Che","sequence":"additional","affiliation":[{"name":"Guangxi Province Postgraduate Co\u2010Training Base for Cooperative Innovation in Basic Medicine (Guilin Medical University &amp; Yueyang Maternal and Child Health\u2010Care Hospital) Yueyang 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