{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:03:39Z","timestamp":1764666219367,"version":"3.46.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10 HD063036","U10 HD063072","U10 HD063047","U10 HD063037","U10HD063041","U10 HD063020","U10 HD063046","U10 HD063048","U10 HD063053"],"award-info":[{"award-number":["U10 HD063036","U10 HD063072","U10 HD063047","U10 HD063037","U10HD063041","U10 HD063020","U10 HD063046","U10 HD063048","U10 HD063053"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between diet and hypertensive disorders of pregnancy (HDP) is inconclusive due incomplete assessment of dietary measures and HDP subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We determined the association between the energy\u2010adjusted Dietary Inflammatory Index (E\u2010DII) and the risk of HDP subtypes in a large, diverse cohort of pregnant individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We completed a secondary analysis of data from the nuMoM2b study. Participants (\n                      <jats:italic>n<\/jats:italic>\n                      = 7309) were recruited from eight sites across the United States in the first trimester and followed through delivery. Participants completed the Block Food Frequency Questionnaire during the first trimester, which assessed the periconceptional period. Calculated macro and micronutrients from the questionnaire were used to calculate E\u2010DII scores. HDP subtypes included gestational hypertension, preeclampsia without severe features, and preeclampsia with severe features. Multivariable ordinal logistic regression models were used to assess the association between E\u2010DII and HDP subtypes, adjusting for baseline age, body mass index, education, race, and ethnicity as a social construct, and insurance status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 7309 assessed individuals, the mean E\u2010DII score was \u22120.61, and the frequency of gestational hypertension was 15.5%, preeclampsia without severe features was 4.3%, and preeclampsia with severe features was 4.1%. A higher E\u2010DII score was associated with greater odds of developing an HDP, with worsening E\u2010DII scores associated with greater odds of experiencing a more severe HDP subtype (adjusted OR = 1.15, 95% CI: 1.08, 1.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a multisite prospective US cohort of nulliparous individuals, higher periconceptional E\u2010DII scores indicative of a pro\u2010inflammatory diet was associated with a slightly increased risk of HDP. And the severity of HDP progressively increased with worsening dietary inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70122","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T13:38:02Z","timestamp":1751981882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Periconceptional Dietary Inflammatory Index and Hypertensive Disorders of Pregnancy and Its Subtype"],"prefix":"10.1111","volume":"94","author":[{"given":"McKenzie K.","family":"Jancsura","sequence":"first","affiliation":[{"name":"Martha S Pitzer Center for Women Children and Youth College of Nursing The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan P.","family":"Helsabeck","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University  Columbus Ohio 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