{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:09:34Z","timestamp":1793945374642,"version":"4.8.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between inflammatory indices derived from complete blood count (CBC) and delivery within 1 week for threatened preterm labor (tPTL) in order to contribute to the management algorithm for women with tPTL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of women with a singleton pregnancy and tPTL admitted to a large tertiary referral hospital between October 1, 2022, and May 31, 2023. After exclusion, the study groups were formed with 42 women who gave birth within 1 week of admission (group 1) and 84 women who gave birth later than 1 week after admission (group 2). The comparison focused mainly on whether there was a difference between the two groups in the systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), and pan\u2010immune inflammation value (PIV), as well as other inflammatory indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Monocyte count, monocyte\u2010to\u2010lymphocyte ratio (MLR), SIRI, and PIV were significantly higher in group 1 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038, 0.019, 0.029, and 0.037, respectively) and receiver operating characteristics curve analysis for discriminatory power to predict PTB within 1 week revealed area under the curve values of 0.613, 0.628, 0.620, and 0.614, respectively. The overall predictive power showed no significant superiority between the individual parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our preliminary results showed an association between increased inflammatory indices and an increased risk of delivery within 1 week in women with tPTL. In particular, SIRI and PIV with cut\u2010off values of &gt;4.3\u00a0\u00d7\u00a010\n                      <jats:sup>3<\/jats:sup>\n                      \/\u00b5L and &gt;677\u00a0\u00d7\u00a010\n                      <jats:sup>6<\/jats:sup>\n                      \/\u00b5L\n                      <jats:sup>2<\/jats:sup>\n                      respectively may facilitate decision\u2010making in the management algorithm for women with tPTL. Further randomized controlled trials with a larger cohort are needed to better define efficacy and limitations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70126","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:49:47Z","timestamp":1751870987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Blood Count\u2010Derived Inflammatory Indices in the Short\u2010Term Prediction of Delivery in Women With Threatened Preterm Labor"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-9099","authenticated-orcid":false,"given":"Murat Levent","family":"Dereli","sequence":"first","affiliation":[{"name":"Department of Perinatology Ministry of Health Denizli State Hospital  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-0136","authenticated-orcid":false,"given":"Sadun","family":"Sucu","sequence":"additional","affiliation":[{"name":"Department of Perinatology University of Health Sciences Ankara Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-5675","authenticated-orcid":false,"given":"Ahmet","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences Ankara Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-0650","authenticated-orcid":false,"given":"Enes","family":"Kumcu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences Ankara Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-543X","authenticated-orcid":false,"given":"Emre","family":"Mat","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Ministry of Health Kartal Doctor L\u00fctfi K\u0131rdar City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3029","authenticated-orcid":false,"given":"Ali","family":"Turhan \u00c7a\u011flar","sequence":"additional","affiliation":[{"name":"Department of Perinatology University of Health Sciences Ankara Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100727"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13836"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06510-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S414305"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07398-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07453-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15696"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31077-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.04.149"},{"key":"e_1_2_8_11_1","unstructured":"World Health Organization.WHO Recommendation on Screening of Pregnant Women for Intrapartum Antibiotic Prophylaxis for the Prevention of Early Onset Group B Streptococcus Disease in Newborns 2024Accessed April 7 2025 https:\/\/iris.who.int\/bitstream\/handle\/10665\/378964\/9789240099128\u2010eng.pdf."},{"key":"e_1_2_8_12_1","unstructured":"American College of Obstetricians and Gynecologists.Prevention of Group B Streptococcal Early\u2010Onset Disease in Newborns Committee Opinion Number 797 2020Accessed April 7 2025 https:\/\/www.acog.org\/\u2010\/media\/project\/acog\/acogorg\/clinical\/files\/committee\u2010opinion\/articles\/2020\/02\/prevention\u2010of\u2010group\u2010b\u2010streptococcal\u2010early\u2010onset\u2010disease\u2010in\u2010newborns.pdf."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12478"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3361"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2024.07.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06701-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13184"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2023.03.014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12822"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.04.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11236982"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07395-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.08.036"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14384"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14993"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2024-0337"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:58:53Z","timestamp":1764665933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/aji.70126"],"URL":"https:\/\/doi.org\/10.1111\/aji.70126","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70126"}}