{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:18:07Z","timestamp":1791231487563,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>A proportion of patients with unexplained recurrent implantation failure (uRIF) may have endometrial immune dysregulation amenable to treatment. Utimpro (Matrice lab Innove, Paris, France) is an endometrial immunophenotype test which identifies the absence or presence and type of immune dysregulation, proposing personalized protocol adjustments for a future embryo transfer (ET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>2.5\u2010year single\u2010center retrospective cohort analysis of 121 patients who underwent Utimpro testing as a pilot study (January 2021\u2014May 2023). Group 1 included 93 patients with uRIF, and Group 2 included 28 patients without RIF. Outcomes from Group 1 were compared to Group 3, a control cohort of 94 uRIF patients, outcomes for Group 2 were compared to Canadian average ongoing pregnancy rates (OPR) per ET. Primary outcome was pregnancy &gt;32\u00a0weeks or live birth. Statistical analyses included the Student <jats:italic>t<\/jats:italic>\u2010test or Mann\u2013Whitney <jats:italic>U<\/jats:italic> test for continuous variables and the Fisher exact test for categorical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group 1, 46\/93 (49.5%) patients had a successful pregnancy compared to control (31\/94 [33%], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026); when stratifying for RIF severity, patients with \u2265\u00a05 failed blastocyst transfers benefitted most from Utimpro (21\/38 [55.3%] vs. control 5\/25 (20.0%), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0084). In Group 2, rates of OPR per ET with Utimpro recommendations did not differ from outcomes for non\u2010RIF patients (9\/28 [32.1%]; 95% CI: 0.15\u20130.52\u00a0vs. 46.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with uRIF, our preliminary findings suggest that application of Utimpro recommendations was associated with a higher rate of successful outcomes; this was not the case for patients without RIF. These findings provide the rationale for an independent randomized controlled trial evaluating the large\u2010scale use of Utimpro in patients with uRIF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70131","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T12:34:37Z","timestamp":1753965277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of Utimpro Testing Implementation for Patients With Unexplained Recurrent Implantation Failure: A Single\u2010Center Retrospective Cohort Study"],"prefix":"10.1111","volume":"94","author":[{"given":"Genevieve","family":"Genest","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology and Allergy Department of Medicine McGill University Health Centre  Montr\u00e9al Qu\u00e9bec 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