{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:16:47Z","timestamp":1758597407318,"version":"3.44.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Interferon\u2010\u03b5 (IFN\u03b5), which is highly abundant in the epithelium of the female reproductive tract (FRT), is a recently identified tumor suppressor for ovarian cancer. IFN\u03b5 induces the expression of certain HLA class I family members in HGSOC (high\u2010grade serous ovarian cancer), and its expression is lost during ovarian tumorigenesis. However, tumor stage\u2013dependent expression of HLA class I family members in ovarian cancer has not been previously studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>Data analysis and visualization were performed using various gene expression and transcriptomics datasets in the R statistical programming environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the expression of HLA\u2010A, \u2010B, \u2010C, \u2010E, \u2010F, \u2010G, and \u2010J is lower in late stage ovarian tumors compared to early\u2010stage tumors. The total expression of HLA class I family members decreases with age in ovarian cancer. Furthermore, we showed that the expression of some IFN\u2010regulated genes, which were shown to be upregulated by IFN\u03b5, decreases from early to late stage in ovarian cancer, in parallel to the loss of IFN\u03b5 expression in ovarian tumorigenesis and possibly in tumor progression. We also found that breast tumors (another hormonally driven cancer) with positive progesterone receptor status have lower IFN\u03b5 mRNA expression compared to those with negative PR status. Besides, we reported that breast tumors with positive estrogen receptor (ER) status have lower expression of IFN\u03b5 compared to those with negative ER status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined, this study points that the decrease in the expression of IFN\u03b5, HLAs, or some other IFN\u03b5\u2010regulated genes during ovarian cancer progression might contribute to worse prognosis in advanced disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70154","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:32:43Z","timestamp":1756992763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of MHC Class I Molecules (HLA\u2010A, \u2010B, \u2010C, \u2010E, \u2010F, \u2010G, and \u2010J) Decreases From Early to Late Stage in Ovarian Cancer"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-5157","authenticated-orcid":false,"given":"Caglar","family":"Berkel","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Tokat Gaziosmanpasa University  Tokat T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006421\u2010w"},{"volume-title":"StatPearls","year":"2022","author":"Becar M.","key":"e_1_2_6_3_1"},{"volume-title":"StatPearls","year":"2023","author":"Nordquist H.","key":"e_1_2_6_4_1"},{"volume-title":"StatPearls","year":"2023","author":"Tumer 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