{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:47:36Z","timestamp":1773254856902,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Placental compromise is a determining factor in the outcome of pregnancies complicated by maternal SARS\u2010CoV\u20102 infection. Chronic histiocytic intervillositis (CHI) is the initial response to SARS\u2010CoV\u20102 infection, but the underlying mechanisms are poorly understood. The aim of this study was to assess the extent and composition of the placental inflammatory response and to explore the relationship between the severity of inflammation and viral levels in the placenta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods of study<\/jats:title>\n                    <jats:p>Placentas from 43 women who tested positive for SARS\u2010CoV\u20102 infection at the time of delivery at a single tertiary medical center (8\/2020 to 10\/2022) were evaluated using quantitative reverse transcription polymerase chain reaction (qRT\u2010PCR), histopathological, ultrastructural, and in situ hybridization studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant association between viral load and severity of CHI with notable involvement of CD20\u2010positive B lymphocytes (100% in patients with diffuse CHI vs 0% in the patients with no inflammation). Both PCR\u2010positive and PCR\u2010negative placentas exhibited varying degrees of inflammation. Electron microscopy confirmed viral particles in PCR\u2010 and CHI\u2010negative samples, Additionally, mean gestational age at delivery was significantly lower in the PCR\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the complex interplay between maternal SARS\u2010CoV\u20102 infection and placental inflammation. The inflammatory response may extend beyond the presence of the virus per se, and viral load differences linked to individual immune response variability may influence the development of inflammation. Further research is needed to elucidate the mechanisms by which SARS\u2010CoV\u20102 impacts maternal and neonatal health outcomes and provide insight into the implications of viral infections during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70215","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:22:12Z","timestamp":1770708132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SARS\u2010CoV\u20102 Chronic Intervillositis: Variations of Maternal Antiviral Response"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-6786","authenticated-orcid":false,"given":"Daria","family":"Kozlova","sequence":"first","affiliation":[{"name":"Department of Pathology Rabin Medical Center \u2013 Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-0653","authenticated-orcid":false,"given":"Ori","family":"Mayer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Shomron","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosef","family":"Azan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rani","family":"Shlayem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv 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