{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:54:57Z","timestamp":1775739297785,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>How does the traditional Chinese compound Bushen Xiaozheng Decoction (BSXZD) affect the immunosuppressive microenvironment in rat endometriosis models?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sprague Dawley rats were randomly divided into normal, sham operation, model, Yasmin, and low\u2010, medium\u2010, high\u2010dose BSXZD groups with 10 rats in each group. The endometriosis model was established by autologous endometrial transplantation, and corresponding interventions were given for 28 days. The volume of ectopic lesions was measured, and histological changes of endometrium were observed by hematoxylin\u2010eosin staining. The protein or gene expression of interleukin\u201010 (IL\u201010) and transforming growth factor\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      (TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) in serum or endometrium was detected by immunohistochemistry, quantitative real\u2010time polymerase chain reaction, Western blotting, and enzyme\u2010linked immunosorbent assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following treatment with BSXZD, the pseudostratified phenomenon and cavity structure of endometrial cells were reduced. Additionally, the expression levels of IL\u201010 and TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      in both endometrium and serum were significantly decreased, accompanied by a marked reduction in the volume of ectopic lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      BSXZD can significantly inhibit the growth of ectopic lesions in a rat model of endometriosis. The underlying mechanism may involve dual regulation of the endocrine\u2010immune axis: it not only directly downregulates the expression of the immunosuppressive factors IL\u201010 and TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      to reversing the local immunosuppressive microenvironment, but also indirectly modulates these cytokines via sex hormone\u2010related signaling pathways. Further studies are needed to clarify the precise molecular mechanism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70223","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:13:13Z","timestamp":1772964793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bushen Xiaozheng Decoction Improves Immunosuppression in a Rat Model of Endometriosis by Reducing IL\u201010 and TGF\u2010\n                    <i>\u03b2<\/i>\n                    Levels"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9002-1148","authenticated-orcid":false,"given":"Feng","family":"Chen","sequence":"first","affiliation":[{"name":"The First Clinical College of Shanxi University of Chinese Medicine  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9248-3316","authenticated-orcid":false,"given":"Yi\u2010Fan","family":"Cui","sequence":"additional","affiliation":[{"name":"Basic Medical College of Shanxi University of Chinese Medicine  Jinzhong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6736-9351","authenticated-orcid":false,"given":"Wen\u2010Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Clinical College of Shanxi University of Chinese Medicine  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27134034"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1562196"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.03.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1657605"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1134663"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01554"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02325-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154847"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119465"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.62347\/RHXV3554"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.13412\/j.cnki.zyyl.20250115.001"},{"key":"e_1_2_10_13_1","volume-title":"Ministry of Health of the People's Republic of China; State Administration of Traditional Chinese Medicine, PRC. 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