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Currently, the anticancer effects of CAR\u2010engineered T cells, macrophages, and NK cells are being intensively explored. Pre\u2010eclampsia (PE) is a pregnancy\u2010specific disease with complex pathogenesis, and no effective treatment exists other than delivery. Placental dysfunction is a major contributing factor; the abnormal placenta releases factors into the maternal bloodstream, leading to systemic inflammation and widespread endothelial dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review comprehensively assesses the therapeutic prospects of CAR\u2010engineered mesenchymal stem cell (CAR\u2010MSC) therapies in addressing the pathophysiological mechanisms of PE, while outlining future directions for CAR\u2010MSC integrated treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Prospects<\/jats:title>\n                    <jats:p>Although non\u2010tumor research based on CAR technology is still in its early stages, in\u2010depth investigation into CAR\u2010MSCs may offer novel insights and perspectives for the treatment of PE by modulating placental immune function and enhancing placental repair. Given that pregnant women constitute a special population, safety considerations must be fully prioritized in future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70236","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:05:49Z","timestamp":1775829949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of Chimeric Antigen Receptor\u2010Engineered Mesenchymal Stem Cell (CAR\u2010MSC) Therapy in the Treatment of Pre\u2010Eclampsia"],"prefix":"10.1111","volume":"95","author":[{"given":"Yixiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine, Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine, Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-0697","authenticated-orcid":false,"given":"Ruizhe","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine, Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31470-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31575-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32335\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-023-00901-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.047"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.07.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27344"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcad065"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57858-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.381"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-0830-6"},{"issue":"11","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276206","article-title":"Impact of Preeclampsia\/Eclampsia on Hemorrhagic and Ischemic Stroke Risk: A 17 Years Follow\u2010Up Nationwide Cohort Study","volume":"17","author":"Chuang C. 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