{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:00:17Z","timestamp":1785085217067,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore correlations between hematological inflammatory indices and oral immunity, systemic immunity, and gut microbiota in healthy term pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty healthy term pregnant women were enrolled. Fecal, saliva, and peripheral blood samples were collected. Hematological inflammatory indices were correlated with immune parameters and gut microbiota using routine blood tests, flow cytometry, cytokine measurements, and 16S rRNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Salivary IL\u20101\u03b2 correlated positively with the Monocyte\u2010to\u2010Lymphocyte Ratio (MLR), the Systemic Immune\u2010Inflammation Index (SII), and the Pan\u2010Immune\u2010Inflammation Value (PIV). The salivary IFN\u2010\u03b3\/IL\u20104 ratio correlated positively with the Hemoglobin\u2010to\u2010Lymphocyte Ratio (HbLR). Peripheral IL\u20105 correlated positively with the Systemic Inflammation Response Index (SIRI) and PIV. CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells correlated with HbLR, while the Th17\/Treg ratio correlated with SII and MLR. Th1\/Th2 ratio and Th1 cells correlated with the derived Neutrophil\u2010to\u2010Lymphocyte Ratio (dNLR) and Neutrophil\u2010to\u2010Lymphocyte Ratio (NLR); conversely, CD56brightCD16\n                      <jats:sup>\u2212<\/jats:sup>\n                      NK cells correlated negatively with SIRI and PIV. Gut microbiota analysis showed negative correlations between\n                      <jats:italic>Collinsella<\/jats:italic>\n                      and SII\/NLR,\n                      <jats:italic>Blautia<\/jats:italic>\n                      and SII, and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      and MLR, while\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      correlated positively with NLR, dNLR, and MLR;\n                      <jats:italic>Phascolarctobacterium<\/jats:italic>\n                      with NLR; and\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      with platelet\u2010to\u2010lymphocyte ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hematological inflammatory indices in healthy term pregnant women are closely associated with oral and systemic immunity, suggesting their potential as indicators of immune balance. These indices also show strong correlations with gut microbiota, indicating that probiotics may help maintain immune homeostasis, whereas certain microbial taxa may promote inflammatory responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70274","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:26:51Z","timestamp":1782656811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Gut Microbiota and Hematological Inflammatory Indices in Full\u2010Term Pregnant Women: An Exploratory Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4801-9824","authenticated-orcid":false,"given":"Guangyu","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"},{"name":"The Reproductive Medical Center Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-4972","authenticated-orcid":false,"given":"Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"},{"name":"Department of Obstetrics Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3612-9831","authenticated-orcid":false,"given":"Xiaomin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3199-5709","authenticated-orcid":false,"given":"Xiaomei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.02.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100897.2005.00268.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.70029"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.104190"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S474154"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12189"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.008"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100897.2010.00836.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.7539"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02976"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104692"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00409"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010703\u20101"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010022\u201004930\u20106"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2009.01516.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100472"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052889"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","unstructured":"W.Wang N.Sung A.Gilman\u2010Sachs andK.\u2010K. 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