{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:00:20Z","timestamp":1785085220382,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preterm premature rupture of membranes (PPROM) is associated with significant maternal and neonatal morbidity, and reliable prognostic biomarkers remain limited. This study aimed to evaluate the prognostic value of complete blood count\u2013derived inflammatory indices in pregnancies complicated by PPROM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 256 singleton PPROM pregnancies managed at a tertiary perinatology center between January 2022 and January 2025. Neutrophil\u2010to\u2010lymphocyte ratio (NLR), systemic immune\u2010inflammation index (SII), systemic immune response index (SIRI), and pan\u2010immune inflammation value (PIV) were calculated from admission blood samples. Previable PPROM cases were analyzed for prediction of birth weight &lt;1000\u00a0g, whereas viable PPROM cases were evaluated for prediction of latency period &lt;4 weeks. Receiver operating characteristic (ROC) and multivariable logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In previable PPROM, NLR and SII were significantly higher in cases with birth weight &lt;1000\u00a0g. ROC analysis demonstrated moderate predictive performance for NLR (AUC 0.76) and SII (AUC 0.75). In viable PPROM cases, higher NLR, SIRI, and PIV were associated with latency &lt;4 weeks, although predictive accuracy was modest (AUC range 0.60\u20130.63). SII showed potential predictive value for chorioamnionitis (AUC 0.79). However, inflammatory indices did not remain significant predictors in multivariable regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Complete blood count\u2013derived inflammatory indices may provide additional information for risk stratification in PPROM; however, their independent prognostic value appears limited and should be interpreted together with clinical findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70284","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:33:07Z","timestamp":1783402387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete Blood Count\u2014Derived Inflammatory Indices and Perinatal Outcomes in Pregnancies With Preterm Premature Rupture of Membranes: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-8535","authenticated-orcid":false,"given":"Orhan","family":"Altinboga","sequence":"first","affiliation":[{"name":"Division of Perinatology Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atakan","family":"Tanacan","sequence":"additional","affiliation":[{"name":"Division of Perinatology Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-3492","authenticated-orcid":false,"given":"Fahri Burcin","family":"Firatligil","sequence":"additional","affiliation":[{"name":"Division of Perinatology Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara 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Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[{"name":"Division of Perinatology Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara 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