{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:08:37Z","timestamp":1787591317779,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>There is a paucity of studies on the incidence and predictors of thrombotic antiphospholipid syndrome (APS) after pregnancy in patients with recurrent pregnancy loss (RPL) and antiphospholipid antibodies (aPL). This prospective study aimed to assess the long\u2010term prognosis, including the occurrence of thrombosis and associated risk factors, in patients with aPL\u2010positive RPL and related obstetric APS manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>We examined patients with RPL and related obstetric APS manifestations who were positive for lupus anticoagulant (LA) based on APTT, Russell's viper venom time (RVVT), or \u03b22glycoprotein I\u2010dependent anticardiolipin antibody (\u03b22GPIaCL) IgG and visited Nagoya City University Hospital from 1994 to 2019. A survey was conducted in 2024 in which patients were asked to complete a questionnaire on the development of APS manifestations based on the American College of Rheumatology\/European Alliance of Associations for Rheumatology classification criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data of 259 of 285 patients (90.5%) who responded to the questionnaire were analysed. The median follows\u2010up duration was 17 (4.6\u201331.1) years. Cumulatively, 9.6% (25\/259) of patients with aPLs and 15.7% (18\/114) of those with obstetric APS experienced thrombotic APS. LA\u2010APTT, LA\u2010RVVT, and\u3000\u03b22GPIaCL IgG were independent predictors of thrombotic APS, with area under the curve values of 0.85 (0.73\u20130.97), 0.93 (0.87\u20130.99), and 0.80 (0.68\u20130.93), respectively. A history of intrauterine foetal death, early\u2010onset preeclampsia, no live birth, thrombosis and complications of systematic lupus erythematosus, and persistent aPL were predictive of thrombotic APS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with RPL and aPL who exhibit the identified risk factors should undergo subsequent follow\u2010up after pregnancy. Further research is required to investigate the potential for thrombosis prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70285","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:21:35Z","timestamp":1783754495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thrombotic Antiphospholipid Syndrome: A Long Term Follow\u2010up of Patients With Recurrent Pregnancy Loss and Antiphospholipid Antibodies From the APS 1994 Study"],"prefix":"10.1111","volume":"96","author":[{"given":"Minami","family":"Ashio","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Medical Sciences Nagoya City University  Mizuho\u2010ku, Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamao","family":"Kitaori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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