{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:21:51Z","timestamp":1787664111161,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Venous thromboembolism (VTE) remains an important cause of maternal morbidity and mortality, yet the diagnosis of deep vein thrombosis (DVT) during pregnancy is challenging because clinical symptoms overlap with physiological gestational changes and D\u2010dimer specificity is reduced. This study evaluated the association between complete blood count\u2010derived systemic inflammatory indices and pregnancy\u2010associated DVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2010control study included 36 pregnant women with Doppler ultrasonography\u2010confirmed DVT and 36 healthy pregnant controls matched for maternal age and gestational age. Neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), systemic immune\u2010inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were calculated from routine complete blood counts. Univariable and multivariable Firth penalized logistic regression analyses were performed, adjusting for body mass index, history of cesarean delivery, and varicose veins. Elastic net penalized regression was used for variable selection. Gestational age\u2010stratified sensitivity analyses, false discovery rate correction, receiver operating characteristic (ROC) analyses, and a supplementary trimester\u2010specific D\u2010dimer threshold analysis were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with DVT had higher NLR, SII, SIRI, AISI, and D\u2010dimer levels than controls, whereas PLR and MLR did not differ significantly. After false discovery rate correction, NLR, SII, SIRI, and AISI remained statistically significant. In multivariable Firth regression, NLR, SII, and D\u2010dimer were independently associated with DVT. Elastic net analysis identified NLR and SII as the most informative inflammatory indices. ROC analyses showed moderate discriminatory performance for NLR and SII, either alone or combined with D\u2010dimer. The gestational age\u2010stratified analyses showed a consistent direction of association, while trimester\u2010specific D\u2010dimer thresholds increased specificity but substantially reduced sensitivity in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR and SII were associated with pregnancy\u2010associated DVT and may reflect the thrombo\u2010inflammatory component of this condition. However, the findings are exploratory and hypothesis\u2010generating. These indices should be considered only as adjunctive markers within the existing diagnostic workflow, not as standalone diagnostic tools. Prospective studies using standardized sampling and pregnancy\u2010adapted D\u2010dimer strategies are needed before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70298","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:01:44Z","timestamp":1787151704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Systemic Inflammatory Indices in Pregnant Women With Deep Vein Thrombosis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-0305","authenticated-orcid":false,"given":"Dilara Sarikaya","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Etlik City Hospital  Ankara T\u00fcrkiye"},{"name":"Department of Obstetrics and Gynecology Mudanya State Hospital  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep 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