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To address inconsistent findings across existing reviews, we conducted an umbrella review of systematic reviews and meta\u2010analyses identified from PubMed, Embase, Web of Science, and the Cochrane Library, with evidence appraised using AMSTAR\u20102 and GRADE. Twenty\u2010one reviews were included. In women with recurrent implantation failure, intrauterine PRP was associated with improved live birth, clinical pregnancy, and biochemical pregnancy rates. Similar benefits were observed in women with previous implantation failure and in assisted reproductive technology (ART) populations. PRP also modestly increased endometrial thickness and implantation rates. In women with thin endometrium or intrauterine adhesions, PRP improved pregnancy outcomes and reduced cycle cancellation, while miscarriage rates were largely unchanged. Intra\u2010ovarian PRP improved ovarian reserve markers, hormone profiles, oocyte yield, and embryo quality in women with poor ovarian response, premature ovarian insufficiency, or diminished ovarian reserve, although effects on pregnancy and live birth were variable. Overall, PRP shows potential benefits, but the certainty of evidence ranged from very low to moderate due to heterogeneity and methodological limitations. High\u2010quality randomized controlled trials are required to confirm efficacy and guide clinical practice.<\/jats:p>","DOI":"10.1111\/aji.70305","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:33:20Z","timestamp":1786721600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Value of Platelet\u2010Rich Plasma Treatment in Reproductive Disorders: An Umbrella Review"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4801-9824","authenticated-orcid":false,"given":"Guangyu","family":"Ma","sequence":"first","affiliation":[{"name":"Reproductive Medical Center Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of Education West China Second University Hospital Sichuan University  Chengdu 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