{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:22:05Z","timestamp":1787664125056,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Inflammation contributes to spontaneous preterm birth, yet mechanisms regulating trophoblast inflammatory responsiveness remain unclear. Interleukin\u20101 beta (IL1\u03b2) is a potent mediator of labor\u2010associated inflammation, but the role of its accessory receptor, IL\u20101 receptor accessory protein (IL\u20101RAP), at the maternal\u2010fetal interface is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>\n                      IL\u20101RAP expression and localization were assessed in preterm chorioamniotic membranes with or without intra\u2010amniotic inflammation. Decidual regulation of trophoblast IL1RAP was evaluated in primary trophoblasts, and gain\u2010 and loss\u2010of\u2010function studies in HTR8\/SV\n                      <jats:sup>neo<\/jats:sup>\n                      cells tested its role in IL\u20101\u03b2\u2010induced inflammatory signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>IL1RAP<\/jats:italic>\n                      expression was increased in fetal membranes from inflammation\u2010associated preterm labor and IL\u20101RAP localized prominently to extravillous trophoblasts. Decidual cell\u2010conditioned media increased trophoblast\n                      <jats:italic>IL1RAP<\/jats:italic>\n                      expression. IL1RAP overexpression enhanced basal and IL\u20101\u03b2\u2010induced expression of inflammatory mediators, including\n                      <jats:italic>TNF<\/jats:italic>\n                      ,\n                      <jats:italic>IL1B<\/jats:italic>\n                      ,\n                      <jats:italic>IL6<\/jats:italic>\n                      , and\n                      <jats:italic>CXCL8\/IL8<\/jats:italic>\n                      , whereas\n                      <jats:italic>IL1RAP<\/jats:italic>\n                      silencing most consistently attenuated IL\u20101\u03b2\u2010induced\n                      <jats:italic>TNF<\/jats:italic>\n                      expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings identify trophoblast IL\u20101RAP as an amplifier of IL\u20101\u03b2\u2010mediated inflammatory signaling and support further investigation of IL\u20101RAP in inflammation\u2010associated preterm birth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70310","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:12:16Z","timestamp":1786979536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u20101 Receptor Accessory Protein Amplifies Trophoblast Inflammatory Signaling in Inflammation\u2010Associated Preterm Birth"],"prefix":"10.1111","volume":"96","author":[{"given":"Jasmine","family":"Edghill","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Cetinkaya\u2010Un","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-7062","authenticated-orcid":false,"given":"Burak","family":"Un","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7197-5241","authenticated-orcid":false,"given":"Isabella","family":"Hetherington","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8065-1046","authenticated-orcid":false,"given":"Md. 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