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Yet, the impact of SARS\u2010CoV\u20102 on the child's immune response remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>Herein, we leverage 833 mother\u2010infant dyads from a New York City\u2010based pregnancy cohort to explore prospective associations between maternal gestational SARS\u2010CoV\u20102 infection and inflammatory biomarkers in newborns. Of the mothers, 100 were infected with SARS\u2010CoV\u20102 during pregnancy, as confirmed through self\u2010report, antibody and\/or PCR test results. We obtained 92 inflammatory biomarker levels in neonatal dried blood spots (DBS) using the Olink Target 96 Inflammation panel. An empirical Bayes method was used to fit linear regression models to assess the effects of maternal infection during pregnancy on neonatal inflammatory markers at birth. We also conducted stratified analyses by timing of infection in early (&lt;20 weeks) versus late (\u226520 weeks) gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher levels of 22 inflammatory biomarkers, including CD5, TNFSF14, CD8a, TGF\u2010\u03b1, and CD244, were observed in neonates prenatally exposed to SARS\u2010CoV\u20102 compared to unexposed neonates (\n                      <jats:italic>\n                        p\n                        <jats:sub>adj<\/jats:sub>\n                      <\/jats:italic>\n                      &lt; 0.05). Early\u2010gestation infection was associated with increased levels of eight inflammatory biomarkers, including TNFSF14, TGF\u2010\u03b1 and decreased IL\u201018 levels, while late\u2010gestation infection was linked to elevations in 12 biomarkers, including CD5, CD6, PD\u2010L1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate that maternal SARS\u2010CoV\u20102 infection during pregnancy influences inflammatory biomarkers in newborns, with the timing of infection playing a critical role in determining these immune profiles. Thus, this study emphasizes the need for further research and long\u2010term follow\u2010up to examine future health consequences for the child.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70313","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:20:32Z","timestamp":1787660432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Gestational Maternal SARS\u2010CoV\u20102 Infection on Neonatal Inflammatory Biomarkers"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2940-1384","authenticated-orcid":false,"given":"Bushra","family":"Amreen","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine Icahn School of Medicine of Mount Sinai  New York New York 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