{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:58:44Z","timestamp":1790585924634,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Problem<\/jats:bold>\n                    : Preterm birth and dysregulated labor remain the leading causes of neonatal morbidity, yet the mechanisms governing progesterone (P4) signaling and inflammatory regulation within the decidua parietalis at the feto\u2010maternal interface are poorly understood. In particular, the roles of progesterone receptor membrane components PGRMC1 and PGRMC2 in maintaining decidual immune homeostasis during pregnancy and labor remain undefined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : of Study:Human decidua parietalis cells were cultured under pregnancy\u2010 and labor\u2010like conditions, with and without immune cell co\u2010culture. Expression of PGRMC1, PGRMC2, and PR\u2010A\/B and their interaction with P4 were assessed. Labor\u2010associated inflammation was modeled using lipopolysaccharide (LPS). SiRNA targeted knockdown of PGRMC2 was performed to evaluate effects on progesterone receptor expression, cell\u2010cycle progression, progesterone metabolism (AKR1C1\/2) and inflammatory cytokine production.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : PGRMC1, PGRMC2, and PR\u2010A\/B expression remained stable across gestational conditions, and P4 robustly interacted with PGRMCs. LPS\u2010induced inflammation was not suppressed by P4 despite preserved receptor expression. PGRMC2 knockdown did not alter progesterone receptor expression, cell\u2010cycle progression, or progesterone metabolism; however, it significantly increased baseline and stimulus\u2010induced IL\u20106 and TNF levels. Under labor\u2010like inflammatory conditions, loss of PGRMC2 markedly amplified cytokine production.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : These findings identify PGRMC2 as an important regulator of decidual immune homeostasis; however, the translational relevance of this role remains limited, as neither our pregnancy nor labor models produced a physiologically meaningful downregulation of PGRMC2 expression. Instead, our data support a model in which parturition\u2010associated changes in decidua are driven primarily by inflammatory cues rather than by loss of progesterone receptor signaling, demonstrating tissue\u2010specific progesterone signaling.\n                  <\/jats:p>","DOI":"10.1111\/aji.70319","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:24:57Z","timestamp":1789597497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Absence of Receptor Mediated Functional Progesterone Withdrawal in the Decidua During Labor\u2010like Inflammatory Conditions"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-3240","authenticated-orcid":false,"given":"Jessica","family":"Selim","sequence":"first","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilu","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rheanna","family":"Urrabaz\u2010Garza","sequence":"additional","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-0224","authenticated-orcid":false,"given":"Glenmarie Angelica S.","family":"Perias","sequence":"additional","affiliation":[{"name":"College of Medicine University of Philippines Manila  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8392-2833","authenticated-orcid":false,"given":"Lauren S.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-8837","authenticated-orcid":false,"given":"Ourlad Alzeus Gaddi","family":"Tantengco","sequence":"additional","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-6105","authenticated-orcid":false,"given":"Ramkumar","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Basic Science and Translational Research Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston  Galveston Texas 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