{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:31:04Z","timestamp":1782927064936,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the incidence of parametrial involvement in women with early\u2010stage cervical cancer with tumour &lt;20\u00a0mm and with negative sentinel lymph nodes (<jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the cases of all women who underwent radical hysterectomy and pelvic lymphadenectomy with <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy for invasive cervical cancer between April 2004 and December 2009. Parametrial involvement was defined as direct extension, nodal disease or spread through vascular channels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 204 women who underwent radical surgery with <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy, 63 (<jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2\u201010, <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>1\u201053) met the inclusion criteria: tumour &lt;20\u00a0mm in the largest diameter regardless of the depth of stromal invasion (less or more than half stromal invasion) and negative sentinel lymph nodes. Median age was 44.3 years (range 24\u201372). Lymph\u2013vascular space invasion was present in 25 women. The histology identified squamous carcinoma in 50 women, adenocarcinoma in 11 women and adenosquamous carcinoma in two women. Tumour grade 1 occurred in 41, grade 2 in 16 and grade 3 in 6 of the cases. No parametrial involvement was observed. The false negative rate of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy was 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No parametrial involvement was observed in women with early\u2010stage cervical cancer with tumour &lt;20\u00a0mm in diameter and negative sentinel lymph nodes regardless of the presence of lymph\u2013vascular space invasion, histology subtype and grade of the tumour. Radical removal of the parametrium in this low\u2010risk group is questionable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12015","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T10:39:30Z","timestamp":1354876770000},"page":"540-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["What is the risk for parametrial involvement in women with early\u2010stage cervical cancer with tumour &lt;20\u00a0mm and with negative sentinel lymph nodes?"],"prefix":"10.1111","volume":"52","author":[{"given":"Jaroslav","family":"Klat","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libor","family":"Sevcik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Simetka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Dvorackova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otakar","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Pathology University Hospital Ostrava Ostrava Czech Republic"},{"name":"Department of Nuclear Medicine University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Castellsagu\u00e9X de Sanjos\u00e9S AguadoTet\u00a0al.HPV and Cervical Cancer in the World. 2008 Report. 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