{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:29:44Z","timestamp":1792168184885,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Metformin is increasingly accepted as an alternative to insulin therapy in gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>). The Metformin in Gestational Diabetes (MiG) trial reported similar pregnancy outcomes for metformin versus insulin; however, supplemental insulin was required in 46% of women on metformin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to identify predictors of response to metformin monotherapy in women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> attending a general hospital antenatal clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We offered extended\u2010release metformin to women diagnosed with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ADIPS<\/jats:styled-content> 1998 criteria) at \u226524\u00a0weeks of gestation. If glucose targets were not achieved (\u22645.0\u00a0mmol\/L fasting, \u22646.7\u00a0mmol\/L two\u2010h post\u2010meal), women were changed to insulin. We carried out an audit to determine characteristics of metformin responders versus nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five women chose initial metformin therapy; 16 (64%) achieved satisfactory glycaemic control (responders). Nine women (36%) were changed to insulin: seven due to inadequate control (nonresponders) and two had metformin intolerance. Fasting glucose at oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) was significantly lower in metformin responders versus nonresponders; two\u2010h glucose and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> did not differ. Ninety\u2010three percent of women with fasting glucose \u22645.2\u00a0mmol\/L responded to metformin: conversely, at fasting glucose &gt;5.2\u00a0mmol\/L, 33% responded (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005). Neonatal outcomes were similar in metformin responders and nonresponders, women who chose initial insulin therapy (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>25), or were diet\u2010controlled (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>, fasting glucose on <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> predicted response to metformin: at fasting glucose \u22645.2\u00a0mmol\/L, the probability of response was 93%. Antenatal clinics should determine locally relevant predictors of response to metformin in women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12018","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T17:13:04Z","timestamp":1354641184000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fasting blood glucose predicts response to extended\u2010release metformin in gestational diabetes mellitus"],"prefix":"10.1111","volume":"53","author":[{"given":"Anne","family":"Corbould","sequence":"first","affiliation":[{"name":"John Morris Diabetes Centre Launceston General Hospital Launceston Tasmania Australia"},{"name":"Faculty of Health Science University of Tasmania Launceston Tasmania 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Dennis","sequence":"additional","affiliation":[{"name":"Faculty of Health Science University of Tasmania Launceston Tasmania Australia"},{"name":"Women's and Children's Service Launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0015"},{"key":"e_1_2_5_3_1","first-page":"676","article-title":"International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"Metzger BE","year":"2010","journal-title":"Diabet 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