{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:14:16Z","timestamp":1772324056573,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Subclinical thyroid hypofunction in pregnancy has been shown to have an association with neurodevelopmental delay in the offspring. It is unclear whether obstetric factors may account for this observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To establish the prevalence of subclinical hypothyroidism (<jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>) in a low\u2010risk primigravid population and to explore its association with obstetric sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Nine hundred and fifty\u2010three primigravid women had thyroid hormone indices analysed in the early second trimester. Delivery and neonatal outcomes were available for 904 women who met the criteria for inclusion in the study. Women with subclinical hypothyroidism (thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) values at or above the 98th percentile with a normal free thyroxine (f<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4)) or isolated maternal hypothyroxinaemia (f<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4 level at or below the second percentile with a normal\u2010range <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) were compared with biochemically euthyroid controls. Chi\u2010squared test and analysis of variance were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> or isolated maternal hypothyroxinaemia was 4%. Positivity for antithyroid peroxidase (<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>) or antithyroglobulin (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) antibodies correlated with <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> status (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Placental abruption was observed more commonly in the setting of either <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content> or isolated maternal hypothyroxinaemia when compared with euthyroid controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 and 0.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subclinical hypothyroidism and isolated maternal hypothyroxinaemia are associated with placental abruption. The observation of these effects in this healthy low\u2010risk population lends weight to the case for antenatal screening for diminished thyroid reserve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12131","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:28:27Z","timestamp":1381541307000},"page":"553-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Subclinical hypothyroidism as a risk factor for placental abruption: Evidence from a low\u2010risk primigravid population"],"prefix":"10.1111","volume":"53","author":[{"given":"Fionnuala M.","family":"Breathnach","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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