{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:02:50Z","timestamp":1782482570784,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T00:00:00Z","timestamp":1382140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>A lipiodol hysterosalpingogram was the routine test for tubal patency as recently as the 1970s. Observational studies, then randomised controlled trials, provided evidence of a fertility enhancing effect of lipiodol. It has been found to improve fertility for women with normal tubal patency, particularly where the woman has a history of endometriosis. Previous successful treatment for infertility with lipiodol is a marker of further successful treatment for infertility in a repeat procedure. Whilst lipiodol is probably effective at flushing debris that could hinder fertility from fallopian tubes, it also exerts immunobiological effects in pelvic peritoneum and on the endometrium that could be responsible for fertility enhancement. Effects of lipiodol on the endometrium that might be important at the time of the implantation window are a reduced expression of osteopontin and an increased number of uterine natural killer cells postlipiodol. The effect of lipiodol uterine bathing for women with endometriosis, repeat <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) implantation failure and other reproductive disorders merits further investigation. Lipiodol presents a new, simple, low invasive, inexpensive treatment option for endometriosis\u2010related infertility and might have wider applications.<\/jats:p>","DOI":"10.1111\/ajo.12141","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T07:36:41Z","timestamp":1382168201000},"page":"9-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Review of lipiodol treatment for infertility \u2013 an innovative treatment for endometriosis\u2010related infertility?"],"prefix":"10.1111","volume":"54","author":[{"given":"Neil P.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Auckland Auckland New Zealand"},{"name":"Auckland Gynaecology Group Auckland New Zealand"},{"name":"Repromed Auckland Auckland New Zealand"},{"name":"Robinson Institute University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)30725-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-38-448-301"},{"issue":"2","key":"e_1_2_5_4_1","first-page":"CD000092","article-title":"Oil\u2010soluble versus water\u2010soluble media for assessing tubal patency with hysterosalpingography or laparoscopy in subfertile women","author":"Vandekerckhove P","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/lps.1991.1.103"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56578-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh418"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12124"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem275"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep045"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det050"},{"issue":"1","key":"e_1_2_5_12_1","first-page":"CD003718","article-title":"Tubal flushing for subfertility","author":"Johnson N","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_5_13_1","first-page":"CD001398","article-title":"Laparoscopic surgery for subfertility associated with endometriosis","author":"Jacobson TZ","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_14_1","first-page":"203","article-title":"Morphology of in vitro sperm phagocytosis by rat peritoneal macrophages under influence of oily contrast medium (Lipiodol)","volume":"25","author":"Mikulska D","year":"1994","journal-title":"Acta Eur Fertil"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03796.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.121"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00692.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der412"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020651"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.065"},{"key":"e_1_2_5_21_1","unstructured":"BaidyaS JohnsonNP PrintCet\u00a0al.Lipiodol uterine bathing effect \u2013 microarray evidence that lipiodol may alter key endometrial gene expression to improve receptivity to implantation. 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