{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:51Z","timestamp":1759565031418},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to review outcomes from <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> (large loop excision of the transformation zone) procedures carried out for high\u2010grade cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>), in particular findings at colposcopy, cytology and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>(high\u2010risk human papilloma virus) result to assess whether colposcopy provides any additional information in the management of women at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed 252 patients who had a <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> procedure for a <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> (high\u2010grade squamous intraepithelial lesion) between January 2005 and December 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty per cent of women who had a <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> procedure for <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> were reviewed in our colposcopy clinic at 12 months after the procedure. Colposcopy at 12 months after <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> was documented as unsatisfactory for 30% of these women. The sensitivity of colposcopy at 12\u00a0months after <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> was 0.47, and the specificity was 0.95.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colposcopy examination is an insensitive tool for detection of persisting <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related change after excision of high\u2010grade <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>. Its usefulness to investigate persistent or recurrent <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> is further reduced by the high rate of unsatisfactory colposcopy examinations after a <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> procedure. <jats:styled-content style=\"fixed-case\">Papanicolaou<\/jats:styled-content> smear and <jats:styled-content style=\"fixed-case\">HRHPV<\/jats:styled-content> tests may be adequate follow\u2010up at 12 months after <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> for women at low risk of recurrence of <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12153","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T06:35:54Z","timestamp":1385966154000},"page":"571-573","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is Colposcopy necessary at twelve months after large loop excision of the transformation zone? 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