{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:18:58Z","timestamp":1772705938425,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prediction of pre\u2010eclampsia and adverse pregnancy outcomes with biomarkers has been proposed. <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> is an ovary\u2010specific growth factor, used to predict ovarian reserve, which changes with age similar to the change in age\u2010related fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the study was to determine whether <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> tested in the first trimester of pregnancy was associated with pregnancy hypertension or adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective cohort study of women who delivered singleton fetuses \u226520\u00a0weeks' gestation at Royal Hospital for Women, Sydney, Australia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0331). <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> was tested in 2011 via Beckman\u2010Coulter Gen <jats:styled-content style=\"fixed-case\">II ELISA<\/jats:styled-content> method on frozen serum collected at the time of first trimester aneuploidy screening (10\u201313\u00a0+\u00a06\u00a0weeks' gestation). Outcome data were obtained from the hospital database (ObstetriX). Main outcome measures were pregnancy hypertension (pre\u2010eclampsia and gestational hypertension) and composite adverse pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> level was 9.7pmol\/L (interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 3.9\u201317.3). There was a trend towards women with pregnancy hypertension having lower <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels than women without pregnancy hypertension (median 5.1pmol\/L, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1.5\u201313.2 vs 9.4 <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 3.9\u201317.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). After adjusting for <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226525, parity \u22651 and age \u226535, women with an <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> less than the 10th centile had a 3.3\u2010fold increased risk of pregnancy hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20138.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). There were no other associations between low <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> concentration and adverse maternal or neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with a very low <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> (1.5\u00a0pmol\/L) in early pregnancy may have an increased risk of pregnancy hypertension. No other adverse pregnancy outcomes were identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12183","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T12:00:33Z","timestamp":1393848033000},"page":"244-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of anti\u2010Mullerian hormone in the first trimester as a predictor for hypertensive disorders of pregnancy and other adverse pregnancy outcomes"],"prefix":"10.1111","volume":"54","author":[{"given":"Antonia W.","family":"Shand","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health UNSW Medicine University of New South Wales Sydney NSW Australia"},{"name":"Department of Maternal\u2010Fetal Medicine Royal Hospital for Women Randwick NSW Australia"},{"name":"Clinical and Population Perinatal Health Research Kolling Institute of Medical Research University of Sydney St Leonards NSW 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