{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:05:56Z","timestamp":1770836756058,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Waikato District Health Board","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Background<\/jats:title>Women requiring thyroid hormone replacement after definitive therapy (surgery or radioiodine) for G<\/jats:styled-content>raves\u2019 disease who later conceive require an early increase in levothyroxine dose and monitoring of thyroid hormone levels throughout pregnancy. In addition, as TSH<\/jats:styled-content> receptor antibodies (TRA<\/jats:styled-content>b) can cross the placenta and affect the fetus, measurement of these antibodies during pregnancy is recommended.<\/jats:p><\/jats:sec>Aim<\/jats:title>To review the management of pregnancies following definitive treatment for G<\/jats:styled-content>raves\u2019 disease in order to assess the rates of maternal hypothyroidism and TRA<\/jats:styled-content>b measurement.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Retrospective chart review of women who had undergone definitive treatment for G<\/jats:styled-content>raves\u2019 disease at a tertiary hospital and subsequently had one or more pregnancies.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 29 women were identified, each of whom had at least one pregnancy since receiving definitive treatment for G<\/jats:styled-content>raves\u2019 disease: there were a total of 49 pregnancies (22 in the surgical group and 27 in the radioiodine group). Both groups had high rates of hypothyroidism documented during pregnancy (47 and 50%, respectively). The surgical group was more likely to be euthyroid around the time of conception. Less than half of the women were referred to an endocrinologist or had TRA<\/jats:styled-content>b measured during pregnancy. Neonatal thyroid function was measured in one\u2010third of live births. One case of neonatal thyrotoxicosis was identified.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Adherence to the current A<\/jats:styled-content>merican T<\/jats:styled-content>hyroid A<\/jats:styled-content>ssociation guidelines is poor. Further education of both patients and clinicians is important to ensure that treatment of women during pregnancy after definitive treatment follows the currently available guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12196","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T12:49:00Z","timestamp":1393505340000},"page":"317-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pregnancy after definitive treatment for G<\/scp>raves\u2019 disease \u2013 Does treatment choice influence outcome?"],"prefix":"10.1111","volume":"54","author":[{"given":"Marianne S.","family":"Elston","sequence":"first","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Waikato Clinical School University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelson","family":"Tu'akoi","sequence":"additional","affiliation":[{"name":"Waikato Clinical School University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goswin Y.","family":"Meyer\u2010Rochow","sequence":"additional","affiliation":[{"name":"Waikato Clinical School University of Auckland Hamilton New Zealand"},{"name":"Department of Surgery Waikato Hospital Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade A.U.","family":"Tamatea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Waikato Clinical School University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V.","family":"Conaglen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Waikato Clinical School University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5912.199"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1954"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2012.06233.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02152.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753451986"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0340"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00639.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0087"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0450"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)01961-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2001.tb01215.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.17.3.456"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2831"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3549"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajo.12196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.12196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:36:45Z","timestamp":1738557405000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.12196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ajo.12196"],"URL":"https:\/\/doi.org\/10.1111\/ajo.12196","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,27]]},"assertion":[{"value":"2013-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}