{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:15:12Z","timestamp":1778328912741,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cell\u2010free <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010based non\u2010invasive prenatal testing for aneuploidy (<jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content>) is now established as the most accurate screening test for trisomy 21. This test became clinically available on a patient\u2010funded basis in Australia and New Zealand in 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinical implementation of <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content> use by members of the Australian Association of Obstetrical and Gynaecological Ultrasonologists (<jats:styled-content style=\"fixed-case\">AAOGU<\/jats:styled-content>) during its first year of local availability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Email invitations with an embedded link to an anonymous online survey were sent to all 140 members of the <jats:styled-content style=\"fixed-case\">AAOGU<\/jats:styled-content> in December 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We received 54 responses to the survey (39% response rate). Two thirds of respondents were subspecialists in obstetric and gynaecological ultrasound or maternal fetal medicine. The majority of respondents had already used NIPT in their practice (94%). There was no significant difference in the proportion of respondents offering NIPT to high\u2010risk women in private versus public practice (95 versus 82%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.14). However, inequity of access due to cost was the most common ethical issue encountered. The vast majority continued to offer an 11\u201313\u00a0week ultrasound in addition to NIPT. Almost all respondents (96%) were also willing to offer NIPT to low\u2010risk women in December 2013 after appropriate genetic counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010invasive prenatal testing was introduced into clinical care by obstetric sonologists with confidence and in accordance with the current recommended guidelines. These results may help inform future prenatal screening policy and cost\u2010effectiveness analyses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12306","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T09:58:14Z","timestamp":1430387894000},"page":"138-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early clinical experience of cell\u2010free DNA\u2010based aneuploidy screening: A survey of obstetric sonologists in Australia and New Zealand"],"prefix":"10.1111","volume":"55","author":[{"given":"Lisa","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Perinatal Medicine The Mercy Hospital for Women Heidelberg Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne Parkville Australia"},{"name":"Public Health Genetics Murdoch Children's Research Institute Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Teoh","sequence":"additional","affiliation":[{"name":"Fetal Diagnostic Unit Monash Medical Centre Clayton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Piessens","sequence":"additional","affiliation":[{"name":"City Imaging Ultrasound for Women East Melbourne Australia"},{"name":"Camberwell Ultrasound for Women Hawthorn East Australia"},{"name":"Central Ultrasound for Women Fitzroy Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine The Mercy Hospital for Women Heidelberg Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358326"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4301"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.065"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2509"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/01.AOG.0000423819.85283.f4","article-title":"American College of Obstetricians and Gynecologists Committee Opinion No. 545: noninvasive prenatal testing for fetal aneuploidy","volume":"120","year":"2012","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4139"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12117"},{"key":"e_1_2_6_9_1","unstructured":"Annual Report. Royal Australian and New Zealand College of Obstetricians and Gynaecologists 2013. [Accessed 29 August 2014.] Available from URL:https:\/\/www.ranzcog.edu.au\/ranzcog-annualreport.html"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14699"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12136"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311037"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.033"},{"issue":"1","key":"e_1_2_6_14_1","first-page":"e1","article-title":"Non\u2010invasive examination of trisomy using directed cell\u2010free DNA analysis: the NEXT study","volume":"34","author":"Norton ME","year":"2014","journal-title":"Prenat Diagn"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000363"},{"key":"e_1_2_6_16_1","unstructured":"Society of Maternal Fetal Medicine Statement: Maternal Serum Cell\u2010Free DNA Screening in Low Risk Women. 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