{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:37:27Z","timestamp":1792658247387,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effect of pregnancy\u2010induced hypertensive disorders on the growth of the placenta on the short and long axes and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study of gross and histological characteristics of placentas and the fetal outcomes of normotensive and hypertensive pregnancies over a three\u2010year period from January 2009 to December 2011 at a tertiary teaching hospital in\n                      <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                      , Australia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Placentas and neonatal outcomes from 100 pregnancies complicated with pregnancy\u2010induced hypertension\/pre\u2010eclampsia were studied and compared with 51 gestational age\u2010matched placentas and neonatal outcomes from normotensive pregnancies. The median maternal age and smoking history were similar in the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.894;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a01.00, respectively). The median pre\u2010pregnancy weight was significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and primiparity more common (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001) in the study group. The median weight of the placenta was significantly lower (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and below the 10th centile (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in the study group. Both the long and short axes of the placental disc were significantly smaller in the study group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\u2264\u00a00.001 respectively). Accelerated villous maturation, placental infarcts and decidual vessel vasculopathy were more common in the study group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The median birthweight and the number of infants with birthweight and length below the 10th centile were significantly higher in the study group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that pregnancy\u2010induced hypertension significantly influences the growth and development of both the placenta and fetus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajo.12308","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T08:45:03Z","timestamp":1433493903000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of pregnancy\u2010induced hypertensive disorders on placental growth along short and long axes and neonatal outcomes"],"prefix":"10.1111","volume":"55","author":[{"given":"Neelkanth","family":"Phad","sequence":"first","affiliation":[{"name":"Department of Neonatology Canberra Hospital Woden Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Dahlstrom","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Canberra Hospital Woden Australian Capital Territory Australia"},{"name":"Australian National University Medical School Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ellwood","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Gold Coast University Hospital Southport Queensland Australia"},{"name":"Griffith University Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Neonatology Canberra Hospital Woden Australian Capital Territory Australia"},{"name":"Australian National University Medical School Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"402","article-title":"Pregnancy\u2010induced hypertension and perinatal mortality","volume":"52","author":"Xiong X","year":"2007","journal-title":"J Reprod Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390506"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40961-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016213"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000024411.22110.AA"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(87)90015-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082833ek"},{"key":"e_1_2_7_11_1","first-page":"471","article-title":"Morphometric study of human placenta in preeclampsia associated with intrauterine growth retardation","volume":"3","author":"Priya G","year":"2012","journal-title":"Int J Pharm Bio Sci"},{"key":"e_1_2_7_12_1","unstructured":"LoweAS BrownMA DekkerGet\u00a0al.Guidelines for the management of hypertensive disorders of pregnancy 2008. 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