{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:11:30Z","timestamp":1788862290503,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Interstitial ectopic pregnancy is a rare but potentially life threatening condition. Of the three management options for this condition (expectant, medical and surgical treatment) methotrexate therapy in several regimens has been reported to be effective and beneficial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the safety and efficacy of intravenous bolus and infusion of methotrexate with folinic acid rescue for the treatment of interstitial ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective cohort study of women with interstitial ectopic pregnancy treated with methotrexate at the Royal Brisbane and Women's Hospital from April 2000 to December 2012. The treatment regimen comprised of a bolus dose of methotrexate 100\u00a0mg followed by 200\u00a0mg of methotrexate infusion over 12\u00a0h. Four doses of 15\u00a0mg oral folinic acid rescue were given post\u2010treatment. Success of methotrexate therapy was confirmed by either a negative serum beta\u2010human chorionic gonadotropin (\u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>) level or subsequent uneventful pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 33 women with interstitial ectopic pregnancy who were treated with this regimen, 31 (93.9%) were treated successfully, including women with a high \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> level up to 106\u00a0634 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L and the presence of fetal cardiac activity. Minor side effects were documented in three cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous methotrexate therapy with folinic acid rescue is well tolerated and highly effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12315","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T07:59:08Z","timestamp":1428998348000},"page":"176-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Management of interstitial ectopic pregnancy with intravenous methotrexate: An extended study of a standardised regimen"],"prefix":"10.1111","volume":"55","author":[{"given":"Keisuke","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baartz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soot Keat","family":"Khoo","sequence":"additional","affiliation":[{"name":"The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3182516d7b"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3224"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182113c10"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822fcc0d"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46349-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00537.x"},{"key":"e_1_2_5_8_1","first-page":"1044","article-title":"Sonographic evolution of cornual pregnancies treated without surgery","volume":"79","author":"Timor\u2010Tritsch IE","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_9_1","unstructured":"National Health and Medical Research Council.When Does Quality Assurance in Health Care Require Independent Ethical Review?2003. 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