{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:27:40Z","timestamp":1770884860584,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The cytotoxic management of ectopic pregnancy using a single dose of intramuscular methotrexate injection has been well established as effective for a select number of women with unruptured tubal ectopic pregnancy where there are minimal symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to create centile curves of serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels following successful treatment with a single dose of 50\u00a0mg\/m<jats:sup>2<\/jats:sup> of intramuscular methotrexate to treat ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Data were retrieved from women treated at the Royal Women's Hospital for ectopic pregnancy between 2006 and 2012. Only women with minimal symptoms, initial serum \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> \u22645000\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L and ectopic mass size of \u226435\u00a0mm on ultrasound were included. Two hundred and fifty\u2010three cases of ectopic pregnancy were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> of women in the study ranged from 18 to 3995\u00a0IU\/L with a median of 497 (25th to 75th centiles; 222\u20131160) IU\/L. The median levels of \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels at day 4, 7 and 14 postmethotrexate injection were 73.8, 47.2 and 10.4% of the initial \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> level, respectively. The 90th centiles of \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> levels at day 4, 7 and 14 were 124.7, 93.8 and 40.0% of initial \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> level, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whilst no comparison with those unsuccessfully treated was made, pending further validation studies, the use of these curves may reduce the reliance on specialist units and streamline care for many women with ectopic pregnancy, such as those whose \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> regress in line with centile values without crossing a certain threshold.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12316","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T12:17:01Z","timestamp":1429618621000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum \u03b2\u2010<scp>hCG<\/scp> levels post\u2010treatment of ectopic pregnancy with a single dose of intramuscular methotrexate"],"prefix":"10.1111","volume":"55","author":[{"given":"Ignatius E.","family":"Hadinata","sequence":"first","affiliation":[{"name":"The Royal Women's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lex W.","family":"Doyle","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital Parkville Victoria Australia"},{"name":"The Department of Obstetrics and Gynaecology The University of Melbourne Melbourne Victoria 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