{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:02:43Z","timestamp":1791849763003,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Uterine leiomyomas are the most common benign tumours in women<jats:bold>.<\/jats:bold> Misoprostol, which is widely used in the treatment and prevention of postpartum haemorrhage in obstetrics, may decrease intra\u2010operative bleeding in abdominal myomectomies when haemorrhage constitutes a challenging problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the effect on intra\u2010operative blood loss of using a single pre\u2010operative dose of rectal misoprostol in abdominal myomectomy surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a randomised double\u2010blind placebo\u2010controlled trial, 50 women undergoing abdominal myomectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of pre\u2010operative of rectal 400\u00a0\u03bcg misoprostol (<jats:italic>n\u00a0<\/jats:italic>=\u00a025) or placebo (<jats:italic>n\u00a0<\/jats:italic>=\u00a025) 1\u00a0h before the operation. The primary outcome was intra\u2010operative blood loss. This clinical trial was registered in clinicaltrial.gov registry with number: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02061657.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010operative blood loss was significantly lower in those women randomised to receive rectal misoprostol versus the placebo group (574\u00a0\u00b1\u00a0194.8\u00a0mL vs 874\u00a0\u00b1\u00a0171.5\u00a0mL). Additionally, the drop in postoperative haemoglobin was significantly less in the misoprostol group (1.7\u00a0\u00b1\u00a00.4 g\/dL) compared with the placebo group (2.1\u00a0\u00b1\u00a00.5 g\/dL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single pre\u2010operative dose of rectal misoprostol (400\u00a0\u03bcg) is a simple applicable method for reducing intra\u2010operative blood loss and operative time in abdominal myomectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12359","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T22:43:32Z","timestamp":1436913812000},"page":"363-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rectal misoprostol for myomectomy: A randomised placebo\u2010controlled study"],"prefix":"10.1111","volume":"55","author":[{"given":"Mohamed","family":"Abdel\u2010Hafeez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elnaggar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ain Shams University Cairo Egypt"},{"name":"Department of Obstetrics and Gynaecology Jersey General Hospital Jersey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Mgeed","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200106000-00022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.06.044"},{"issue":"11","key":"e_1_2_7_4_1","first-page":"CD005355","article-title":"Interventions to reduce haemorrhage during myomectomy for fibroids","author":"Kongnyuy EJ","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb11918.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.06.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00296-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000132801.41880.e8"},{"key":"e_1_2_7_9_1","first-page":"275","article-title":"Comparison between oral and vaginal administration of misoprostol on uterine contractility","volume":"93","author":"Danielsson KG","year":"1998","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(77)90026-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00076-1"},{"key":"e_1_2_7_12_1","first-page":"46","article-title":"Intravaginal misoprostol reduces intraoperative blood loss in minimally invasive myomectomy: a randomized clinical trial","volume":"38","author":"Kalogiannidis I","year":"2011","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.09.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01304.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.03.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.03.025"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600985032"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00111-7"},{"key":"e_1_2_7_20_1","first-page":"720","article-title":"Treatment of leiomyomata uteri with leuprolide acetate depot: a double\u2010blind, placebo\u2010controlled, multicenter study. 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