{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:33:30Z","timestamp":1775176410291,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary dysmenorrhoea, the most common gynaecologic problem of adolescent females, is commonly treated with nonsteroidal anti\u2010inflammatory drugs or oral contraceptive pills.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the effect of zinc sulphate with that of placebo on the control of pain severity and duration in adolescent girls with primary dysmenorrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a three\u2010month randomised double\u2010blind placebo\u2010controlled clinical trial, 120 adolescent females with primary dysmenorrhoea were randomly divided into two groups of sixty: an intervention group (zinc) and a control group (placebo). Zinc was administered in the form of a capsule containing 50\u00a0mg\/day zinc sulphate beginning on the first day of menses and continuing until three days prior to the end of menses. Each month, the duration and severity of primary dysmenorrhoea were determined. Severity scoring was performed by using a 0\u201310 scaling system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first month, the duration of pain was significantly lower in the zinc group compared with the placebo group (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.044), while there was no significant difference in pain severity between the groups (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.497). In the second and third month, pain severity and duration in the zinc group were significantly lower than the placebo group (<jats:italic>P<\/jats:italic>\u2010value &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both pain duration and pain severity were decreased by taking oral zinc. The results of our interventional study suggests that zinc may be used to treat primary dysmenorrhoea in adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12367","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T09:13:01Z","timestamp":1435655581000},"page":"369-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A randomised controlled trial of oral zinc sulphate for primary dysmenorrhoea in adolescent females"],"prefix":"10.1111","volume":"55","author":[{"given":"Omid R.","family":"Zekavat","sequence":"first","affiliation":[{"name":"Pediatric department Jahrom university of medical sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Y.","family":"Karimi","sequence":"additional","affiliation":[{"name":"Student research committee Jahrom university of medical sciences Jahrom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Amanat","sequence":"additional","affiliation":[{"name":"Student research committee Jahrom university of medical sciences Jahrom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Alipour","sequence":"additional","affiliation":[{"name":"Student research committee Jahrom university of medical sciences Jahrom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104473"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.02.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1059840509349723"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.12.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200810010-00001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00839.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1542\/peds.70.4.516","article-title":"Current status of etiology and management of dysmenorrhea in dolescents","volume":"70","author":"Alvin PE","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2004.30052.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30395-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10210.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90576-3"},{"key":"e_1_2_7_13_1","first-page":"CD002120","article-title":"Oral contraceptive pill for primary dysmenorrhoea","volume":"4","author":"Wong CL","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090495"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7041342"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.06.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.7.1709"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji006"},{"key":"e_1_2_7_20_1","first-page":"1541","article-title":"Management of chroric pelvic inflammatory disease with shortwave diathermy","volume":"68","author":"Balogun JA","year":"1988","journal-title":"Phys Ther"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-4-200008150-00006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod28.4.883"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90111-9"},{"key":"e_1_2_7_24_1","first-page":"CD001751","article-title":"Nonsteroidal anti\u2010inflammatory drugs for dysmenorrhoea","volume":"1","author":"Marjoribanks J","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.1.2.105"},{"key":"e_1_2_7_26_1","unstructured":"National Institutes of Health Office of Dietary Supplements[Homepage on the Internet].Zinc: Dietary supplement fact sheet for health professionals.Washington DC[Updated: 20th Sept 2011; Cited: 12th January 2012]. 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