{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:18:43Z","timestamp":1790021923617,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have described an association between sperm with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage and a history of recurrent miscarriage (<jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>), although it is not clear whether there is benefit in screening for sperm <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation and to what extent <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation impacts upon <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify what proportion of couples experiencing <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content> are affected by <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this retrospective study, between 2008 and 2013, couples with a history of recurrent miscarriage (\u22653 first trimester miscarriages) were investigated comprehensively for known causes (karyotype, uterine, antiphospholipid syndrome, thrombophilia) and also by semen analysis, including <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation [sperm chromatin structure analysis (<jats:styled-content style=\"fixed-case\">SCSA<\/jats:styled-content>)]. Statistical analysis was performed on <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> software with significance taken as <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 108 couples with a median sperm <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation index (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>) of 9.50%. Normal levels were found in 70.5% of men (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\u00a0&lt;\u00a015%), 23% had high levels (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> 15\u201330%), and 6.5% had very high levels (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\u00a0&gt;\u00a030%). Couples with otherwise unexplained recurrent miscarriage had significantly higher <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> than those with other causes identified on routine screening (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In couples experiencing <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>, 30% (32\/108) of men had sperm with high levels of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\u00a0&gt;\u00a015%). This may be a contributing factor to the clinical syndrome of <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>, and future clinical trials of therapies for these couples are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12373","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T08:22:50Z","timestamp":1437639770000},"page":"379-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sperm <scp>DNA<\/scp> fragmentation abnormalities in men from couples with a history of recurrent miscarriage"],"prefix":"10.1111","volume":"55","author":[{"given":"Mikaela","family":"Leach","sequence":"first","affiliation":[{"name":"University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Sacks","sequence":"additional","affiliation":[{"name":"University of New South Wales Sydney NSW Australia"},{"name":"St George Hospital Kogarah Sydney NSW Australia"},{"name":"Royal Hospital for Women Randwick NSW Australia"},{"name":"IVFAustralia Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-F"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1990-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq098"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32813e3ff0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.05.049"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.01.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.4.1039"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.057"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap059"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.161"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.10.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.03.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00041.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9282-y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01485010290099390"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.05.042"},{"key":"e_1_2_6_18_1","first-page":"267","article-title":"Idiopathic recurrent pregnancy loss: role of paternal factors. 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