{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:24:15Z","timestamp":1780730655244,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Gestational hypertensive disease (<jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>) is associated with pregnancy\u2010related complications and poor maternal and fetal outcomes in singleton pregnancies. We sought to examine the influence of <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> in a large prospective cohort of twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ESPR<\/jats:styled-content>IT study was a national multicenter observational cohort study of 1028 structurally normal twin pregnancies. Each pregnancy underwent sonographic surveillance with two\u2010week ultrasound from 24 weeks for dichorionic and from 16 weeks for monochorionic gestations. Characteristics and demographics as well as labour and delivery outcome data were prospectively recorded. Perinatal mortality, admission to the neonatal intensive care unit (NICU) and a composite of morbidity of respiratory distress syndrome, hypoxic ischaemic encephalopathy, periventricular leukomalacia, necrotising enterocolitis and sepsis were documented for all cases. Outcomes for patients with documented <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> (pre\u2010eclampsia and gestational hypertension) were compared with those without <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Perinatal outcome data were recorded for 977 patients. Women with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> had a higher body mass index (27.1 \u00b1 6.4 vs 25.2 \u00b1 4.5, <jats:italic>P<\/jats:italic> &lt; 0.0001) than those without and were more likely to be nulliparous (65% (59\/92) vs 46% (407\/885), <jats:italic>P<\/jats:italic> = 0.001). Both groups had similar mean birthweights, but those with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> were more likely to have a birthweight discordance \u226518% (35% (32\/92) vs 20% (179\/885), <jats:italic>P<\/jats:italic> = 0.001). Rates of caesarean delivery were higher in those twin pregnancies affected by <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>, and while the rate of composite morbidity was similar in both groups, twins in the <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> group had higher rates of <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In twin gestations, gestational hypertension independently confers an increased risk for emergency caesarean delivery, birthweight discordance and <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admission, such that intensive maternal\u2013fetal monitoring is justified when hypertension develops in a twin pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12483","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T16:10:37Z","timestamp":1466007037000},"page":"466-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gestational hypertensive disease in twin pregnancy: Influence on outcomes in a large national prospective cohort"],"prefix":"10.1111","volume":"56","author":[{"given":"Mark P.","family":"Hehir","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionnuala M.","family":"Breathnach","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionnuala M.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College Dublin School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Geary","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Rotunda Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Coombe Women's and Infants\u2019 University Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College Cork Cork 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