{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:28:26Z","timestamp":1774085306448,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Conception using assisted reproduction treatments (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>) has been associated with an increased risk of pregnancy complications. It is uncertain if this is caused by <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> directly, or is an association of the underlying factors causing infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We assessed the relationship between assisted conception (AC) and maternal or fetal complications in a large retrospective cohort study. In a nested cohort of women receiving infertility treatment, we determined if such risk rests predominantly with certain causes of infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective database analysis of 50 381 women delivering a singleton pregnancy in four public hospital obstetric units in western Sydney, and a nested cohort of 508 women receiving <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> at a single fertility centre, in whom the cause of infertility was known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1727 pregnancies followed <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>; 48 654 were spontaneous conceptions. Adjusted for age, <jats:styled-content style=\"fixed-case\">body mass index<\/jats:styled-content> and smoking, <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> was associated with increased risk of preterm delivery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.73, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.50\u20132.02), hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.55, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.34\u20131.82) and diabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.51, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.30\u20131.75). In the nested cohort, ovulatory dysfunction was present in 145 women and 336 had infertility despite normal ovulatory function. Ovulatory dysfunction was associated with increased risk of diabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.94, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.72\u20135.02) and hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.15\u20135.00) compared to women with normal ovulatory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assisted conception is associated with increased risk of pregnancy complications. This risk appears greatest for women whose underlying infertility involves ovulatory dysfunction. Such disorders probably predispose towards diabetes and hypertension, which is then exacerbated by pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12494","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T09:36:35Z","timestamp":1468229795000},"page":"286-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ovulatory disorders are an independent risk factor for pregnancy complications in women receiving assisted reproduction treatments"],"prefix":"10.1111","volume":"57","author":[{"given":"Sumita","family":"Barua","sequence":"first","affiliation":[{"name":"Westmead Hospital Westmead NSW Australia"},{"name":"School of Medicine, Western Sydney University Campbelltown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Ming","family":"Hng","sequence":"additional","affiliation":[{"name":"Blacktown Hospital Blacktown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Smith","sequence":"additional","affiliation":[{"name":"Westmead Hospital Westmead NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bradford","sequence":"additional","affiliation":[{"name":"Blacktown Hospital Blacktown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"McLean","sequence":"additional","affiliation":[{"name":"School of Medicine, Western Sydney University Campbelltown Australia"},{"name":"Blacktown Hospital Blacktown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem046"},{"key":"e_1_2_6_3_1","unstructured":"LiZ McNallyL HilderL SullivanE.Australia's mothers and babies 2009. 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