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Micronised progesterone (<jats:styled-content style=\"fixed-case\">mP<\/jats:styled-content>4) has been available in Europe since the 1990s and clinical trials have shown that 100\u00a0mg oral daily, 200\u00a0mg oral sequentially or 100\u00a0mg vaginal every second day effectively protect the endometrium from the stimulatory effects of oestrogen. <jats:styled-content style=\"fixed-case\">MHT<\/jats:styled-content> containing <jats:styled-content style=\"fixed-case\">mP<\/jats:styled-content>4 has a significantly lower breast cancer risk than those containing progestins. Micronised progesterone does not appear to attenuate the cardiovascular benefits of oestrogen. 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