{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:55:11Z","timestamp":1791428111353,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Marie Stopes International in Australia"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In 2014, a composite pack containing mifepristone\u2010buccal misoprostol, indicated for use to 63\u00a0days gestation replaced the existing regimen for early medical abortion (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>) in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To provide updated efficacy and safety information for the use of mifepristone\u2013buccal misoprostol for <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> in Australia, and assess the effect of patient age and gestational age on efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Observational cohort study of 15\u00a0008 women attending one of 16 Marie Stopes International clinics in Australia for an <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> (gestational age\u00a0\u2264\u00a063\u00a0days) between 1 March 2013 and 30 September 2015. Administration of 200\u00a0mg oral mifepristone in\u2010clinic was followed 24\u201348\u00a0h later by 800\u00a0\u03bcg buccal misoprostol self\u2010administered at home. Method success was defined as complete abortion not requiring surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up information was available for 87.14% (13\u00a0078\/15\u00a0008) of women. Likelihood of follow\u2010up was significantly lower for women from rural or remote locations (adjusted odds ratio, 0.47; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Medical abortion was successful in 95.16% (12\u00a0445\/13\u00a0078) of women with follow\u2010up. Higher patient and gestational ages were associated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) with a slight increase in method failure. There were 674 serious adverse events (5.15%), mainly due to method failure. Infection (15; 0.11%) and haemorrhage (17; 0.13%) were rare. One death was recorded (&lt;0.01%); however, an association between <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> and cause of death, necrotising pneumonia, was not established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mifepristone\u2013buccal misoprostol is an effective and safe alternative to surgical termination of pregnancy up to 63\u00a0days gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12608","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T06:02:41Z","timestamp":1489730561000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy and safety of mifepristone\u2013buccal misoprostol for early medical abortion in an Australian clinical setting"],"prefix":"10.1111","volume":"57","author":[{"given":"Philip","family":"Goldstone","sequence":"first","affiliation":[{"name":"Marie Stopes International in Australia  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Walker","sequence":"additional","affiliation":[{"name":"MS Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hawtin","sequence":"additional","affiliation":[{"name":"MS Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.The use of mifepristone for medical termination of pregnancy (C\u2010Gyn 21).Melbourne Australia:RANZCOG 2013."},{"key":"e_1_2_7_3_1","volume-title":"Clinical Practice Handbook for Safe Abortion","author":"World Health Organization","year":"2014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01179.x"},{"key":"e_1_2_7_5_1","unstructured":"Mifepristone Linepharma 200\u00a0mg Tablet [Product Information].Melbourne Australia:MS Health 2012. 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