{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:12:13Z","timestamp":1789596733284,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although the patient perspective is implicit in the practice of medicine, research evaluating this remains scarce. In a climate where clinicians and policy\u2010makers constantly strive to achieve more patient\u2010centred models of care, this omission warrants attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess health\u2010related quality of life (Hr<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>) in women under 25\u00a0years of age with cervical intra\u2010epithelial neoplasia grade 2 (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2) receiving conservative management (colposcopy follow\u2010up, with treatment if necessary) compared with those receiving immediate excisional treatment with large loop excision of the transformation zone (<jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational study evaluating Hr<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> was conducted at Christchurch Women's Hospital, New Zealand. Women undergoing conservative management for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 were compared with those undergoing immediate excisional treatment in an age\u2010matched sample. The Short Form Health Survey 12 version 2 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012v2) was used to evaluate Hr<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>. Secondary outcomes of anxiety and sexual function were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four women with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 participated in the study. Of these, 63 (60%) received conservative management and 41 (40%) received immediate excisional treatment with <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>. We found no significant difference in Hr<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> between the groups in a multivariate regression analysis adjusted for parity, smoking and socioeconomic status. There were also no significant differences in sexual function or anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no difference in Hr<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> by management strategy. Conservative management of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 in women under 25 is unlikely to have an adverse impact on self\u2010reported HrQoL, anxiety or sexual functioning compared with conventional management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12633","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T07:36:41Z","timestamp":1494920201000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Initial observation of <scp>CIN<\/scp>2 does not appear to reduce quality of life in women under 25\u00a0years of age"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-0069","authenticated-orcid":false,"given":"Katayoun","family":"Taghavi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Christchurch Women's Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ra","family":"Morell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Christchurch Women's Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"MacNab","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Christchurch Women's Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Innes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Williman","sequence":"additional","affiliation":[{"name":"Department of Population Health University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony","family":"Simcock","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sykes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Christchurch Women's Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03344.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2003.09.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602411"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.069"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fe777f"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.09.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.05.005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12835"},{"key":"e_1_2_5_13_1","unstructured":"EnglandPH.Colposcopy and programme management guidelines for the NHS cervical screening programme Cervical screening: professional guidance 2009."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.633"},{"key":"e_1_2_5_15_1","unstructured":"LewisH FentimanG BethwaiteP.Guidelines for cervical screening New Zealand 2013: National screening unit Ministry of Health. 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