{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:08:20Z","timestamp":1775196500234,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the effect of adjuvants during intensive vaginal dilator therapy for functional and anatomical neovagina creation in women with Mayer\u2010Rokitansky\u2010Kuster\u2010Hauser syndrome (<jats:styled-content style=\"fixed-case\">MRKH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included 75 women with <jats:styled-content style=\"fixed-case\">MRKH<\/jats:styled-content> undergoing intensive vaginal dilator treatment between 2000 and 2014. One specialist nurse performed non\u2010surgical vaginal dilation aided by adjuvants, during inpatient admissions for several dilation sessions per day. Following discharge, women continued dilation at home and were advised to attend fortnightly follow\u2010up appointments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Outcomes from 68 women were analysed. The median age of starting treatment was 18\u00a0years (range: 13\u201336). There was a mean of 3\u00a0days per admission (range 1\u20135) with a median of 10 dilation sessions per admission. Adjuvant treatment was used by 48\/68 (71%) women: oestriol cream 29\/68 (43%), 50:50 nitrous oxide and oxygen 44\/68 (65%), diazepam 8\/68 (12%), lidocaine ointment 26\/68 (39%), paracetamol 35\/68 (51%) and naproxen 2\/68 (3%). There were no statistically significant differences for changes in vaginal parameters. Women receiving adjuvants had a median increase of 4.5\u00a0cm (0.5\u20137\u00a0cm) in neovaginal length compared with women not receiving adjuvants who had a median increase of 3.25\u00a0cm (0\u20137\u00a0cm) during intensive treatment. Women who received adjuvants tolerated more dilation sessions per day (10 vs 6.5 median sessions respectively) than those who did not (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Of those with documented length at discharge, 42\/56 (75%) women had an anatomical neovagina of 7\u00a0cm or greater length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaginal dilation delivered by intensive treatment and supplemented by adjuvant treatments in a multi\u2010disciplinary centre is a rapid and effective method for creation of a neovagina in women with <jats:styled-content style=\"fixed-case\">MRKH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12715","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:52:27Z","timestamp":1506613947000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intensive vaginal dilation using adjuvant treatments in women with Mayer\u2010Rokitansky\u2010Kuster\u2010Hauser syndrome: retrospective cohort study"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-0221","authenticated-orcid":false,"given":"Ashradha","family":"Ketheeswaran","sequence":"first","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Morrisey","sequence":"additional","affiliation":[{"name":"Paediatric and Adolescent Gynaecology Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Abbott","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Paediatric and Adolescent Gynaecology Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Dudley","sequence":"additional","affiliation":[{"name":"Paediatric and Adolescent Gynaecology Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Deans","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Paediatric and Adolescent Gynaecology Royal Hospital for Women  Sydney New South Wales 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