{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T19:25:30Z","timestamp":1751397930029,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T00:00:00Z","timestamp":1512691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare birth weights in central Sydney to the <jats:styled-content style=\"fixed-case\">INTERGROWTH<\/jats:styled-content>21st international standard to describe current trends in relation to optimal growth and to define areas that may benefit from improved obstetric surveillance and intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of prospectively collected cohort. Design: hospital\u2010based cohort study. Setting: Sydney Local Health District, Australia. Population or sample: women with singleton pregnancies who had first trimester screening for aneuploidy between 16 April, 2010 and 9 March, 2012. Analysis of 2966 births. Main outcome measures: Large for gestational age (<jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content>) &gt;4000\u00a0g, &gt;4500\u00a0g, &gt;5000\u00a0g, &gt;90th, &gt;95th, &gt;97th centiles and small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) &lt;1500\u00a0g, &lt;2500\u00a0g, &lt;third, &lt;fifth, &lt;10th centiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of infants classified as <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> was significantly higher than expected by the international standard, with relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s) of 1.66 (1.44\u20131.88), 1.81 (1.50\u20132.21) and 2.07 (1.61\u20132.65) for the 90th, 95th and 97th centiles, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). The number of infants classified as <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> was significantly lower with <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s of 0.32 (0.21\u20130.49), 0.38 (0.28\u20130.52) and 0.45 (0.37\u20130.55) for the 3rd, 5th and 10th centiles, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Maternal body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and height were significantly associated with <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> infants as were parity and pre\u2010existing diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comparing the international INTERGROWTH21st standards to our population has revealed a markedly high prevalence of <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> infants. The most important modifiable risk factors identified in early pregnancy were maternal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and pre\u2010existing diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.12748","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T05:23:23Z","timestamp":1512710603000},"page":"506-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemic of large babies highlighted by use of <scp>INTERGROWTH<\/scp>21st international standard"],"prefix":"10.1111","volume":"58","author":[{"given":"Felicity J.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine John Hunter Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-0170","authenticated-orcid":false,"given":"Brad","family":"de 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